2,5-Dimethoxythiophenol

Base Information

• Chemical Name: 2,5-Dimethoxythiophenol
• CAS No.: 1483-27-8
• Molecular Formula: C8H10O2S
• Molecular Weight: 170.232
• Hs Code.: 2930909090
• Mol file: 1483-27-8.mol

Synonyms:2,5-Dimethoxybenzenethiol;Benzenethiol,2,5-dimethoxy-;

Chemical Property of 2,5-Dimethoxythiophenol

Chemical Property:

• Vapor Pressure: 0.00707mmHg at 25°C
• Melting Point: 248.3-252.0 °C (decomp)
• Refractive Index: n20/D 1.5860(lit.)
• Boiling Point: 278.8°Cat760mmHg
• PKA: 6.37±0.48(Predicted)
• Flash Point: 122.4°C
• PSA: 57.26000
• Density: 1.134g/cm³
• LogP: 1.99250
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Sensitive.: Stench
• Solubility.: Chloroform, Methanol

Purity/Quality:

99% ^*data from raw suppliers

2,5-Dimethoxythiophenol ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2,5-Dimethoxythiophenol is a thiophenol derivative used in the preparation of dihydrofolate reductase inhibitors and potential antitumor agents.

Technology Process of 2,5-Dimethoxythiophenol

There total 8 articles about 2,5-Dimethoxythiophenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2,5-dimethoxybenzene-1-sulfonyl chloride (1483-28-9) → 2,5-dimethoxythiophenol (1483-27-8)

Guidance literature:

With hydrogenchloride; zinc;

DOI:10.1021/jm0493109

Reference yield:

concentrated H2 SO4 + 2,5-dimethoxybenzene-1-sulfonyl chloride (1483-28-9) → 2,5-dimethoxythiophenol (1483-27-8)

Guidance literature:

With zinc; In tetrahydrofuran; water;

Reference yield:

1,4-dimethoxybezene (150-78-7) → 2,5-dimethoxythiophenol (1483-27-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 68.3 percent / aq. HOSO₂Cl

2: 99 percent / Zn; aq. HCl

With hydrogenchloride; chlorosulfonic acid; zinc;

DOI:10.1021/jm0493109

upstream raw materials:

2,5-dimethoxyaniline

1-bromo-2,5-dimethoxybenzene

2,5-dimethoxybenzene-1-sulfonyl chloride

potassium ethyl xanthogenate

Downstream raw materials:

1,4-dimethoxy-2-(methylsulfonyl)benzene

2-isopentylsulfanyl-1,4-dimethoxy-benzene

5,8-dimethoxy-2-(4-methoxy-phenyl)-thiochromen-4-one

4-(2,5-dimethoxy-phenylsulfanylmethyl)-morpholine

Refernces

• 1、 Gallardo-Godoy, Alejandra,Fierro, Angélica,McLean, Thomas H.,Castillo, Mariano,Cassels, Bruce K.,Reyes-Parada, Miguel,Nichols, David E.. "Sulfur-substituted α-alkyl phenethylamines as selective and reversible MAO-A inhibitors: Biological activities, CoMFA analysis, and active site modeling". . p. 2407 - 2419. Retrieved 2007/10/03.
• 2、 Bock, Hans,Rittmeyer, Peter. "RADIKALIONEN 89. EINELEKTRONEN-OXIDATIONEN VON DIARYLDISULFIDEN MIT AlCl3/H2CCl2". . p. 261 - 292. Retrieved 2007/10/02.