1H-Indole-1-carboxylic acid, 6-(bromomethyl)-, 1,1-dimethylethyl ester

Base Information

Chemical Name:1H-Indole-1-carboxylic acid, 6-(bromomethyl)-, 1,1-dimethylethyl ester
CAS No.:127956-25-6
Molecular Formula:C₁₄H₁₆BrNO₂
Molecular Weight:310.191
Hs Code.:
European Community (EC) Number:830-487-2

Synonyms:127956-25-6;1H-Indole-1-carboxylic acid, 6-(bromomethyl)-, 1,1-dimethylethyl ester;tert-butyl 6-(bromomethyl)-1H-indole-1-carboxylate;tert-butyl 6-(bromomethyl)indole-1-carboxylate;CFA95625;AKOS037644170;AS-48031;EN300-309429;F17569;6-Bromomethyl-indole-1-carboxylic acid tert-butyl ester

Suppliers and Price of 1H-Indole-1-carboxylic acid, 6-(bromomethyl)-, 1,1-dimethylethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

AK Scientific
1H-Indole-1-carboxylicacid,6-(bromomethyl)-,1,1-dimethylethylester
500mg
$ 671.00

AK Scientific
1H-Indole-1-carboxylicacid,6-(bromomethyl)-,1,1-dimethylethylester
250mg
$ 399.00

Total 2 raw suppliers

Chemical Property of 1H-Indole-1-carboxylic acid, 6-(bromomethyl)-, 1,1-dimethylethyl ester

Chemical Property:

XLogP3:3.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:309.03644
Heavy Atom Count:18
Complexity:313

Purity/Quality:

More than 98% ^*data from raw suppliers

1H-Indole-1-carboxylicacid,6-(bromomethyl)-,1,1-dimethylethylester ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1C=CC2=C1C=C(C=C2)CBr

Technology Process of 1H-Indole-1-carboxylic acid, 6-(bromomethyl)-, 1,1-dimethylethyl ester

There total 7 articles about 1H-Indole-1-carboxylic acid, 6-(bromomethyl)-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 127956-24-5
tert-butyl 6-methyl-1H-indole-1-carboxylate

: 127956-25-6
6-(bromomethyl)-1-(tert-butoxycarbonyl)indole

Guidance literature:: With N-Bromosuccinimide; dibenzoyl peroxide; In tetrachloromethane; at 80 ℃; for 0.416667h; Irradiation;
DOI:10.1016/S0040-4039(01)93319-2

Reference yield:

: 354587-72-7
tert-butyl 6-(hydroxymethyl)-1H-indole-1-carboxylate

: 127956-25-6
6-(bromomethyl)-1-(tert-butoxycarbonyl)indole

Guidance literature:: With phosphorus tribromide; In dichloromethane; at -10 - 20 ℃; Inert atmosphere;
DOI:10.1016/j.tetlet.2021.153516

Reference yield:

: 3420-02-8
6-methylindole

: 127956-25-6
6-(bromomethyl)-1-(tert-butoxycarbonyl)indole

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / 4-DMAP

2: 69 percent / NBS/dibenzoyl peroxide / CCl₄ / 0.42 h / 80 °C / Irradiation

With N-Bromosuccinimide; dibenzoyl peroxide; dmap; In tetrachloromethane;
DOI:10.1016/S0040-4039(01)93319-2