Technology Process of cis-2-amino-cis-5-phenoxycyclopentanol hydrochloride
There total 10 articles about cis-2-amino-cis-5-phenoxycyclopentanol hydrochloride which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
various solvent(s);
for 24h;
Heating;
DOI:10.1021/jo00217a017
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 57 percent / vanadyl acetylacetonate, tert-butyl hydroperoxide / benzene / 1.) 80 deg C, 15 min, 2.) 40 deg C, 5 h
2: 79.5 percent / triphenylphosphine, isopropyl azocarboxylate / tetrahydrofuran / 24 h / Ambient temperature
3: 87 percent / sodium azide, ammonium chloride / ethanol; H2O / 16 h / Heating
4: hydrogen / 5percent Pd/C / ethanol / 16 h
5: 75 percent / triethylamine / diethyl ether; tetrahydrofuran / 0.17 h
6: 80 percent / SOCl2 / 2 h / 40 °C
7: 85 percent / 5N HCl / various solvent(s) / 24 h / Heating
With
hydrogenchloride; tert.-butylhydroperoxide; thionyl chloride; sodium azide; di-isopropyl azodicarboxylate; vanadyl acetylacetonate; ammonium chloride; hydrogen; triethylamine; triphenylphosphine;
palladium on activated charcoal;
In
tetrahydrofuran; diethyl ether; ethanol; water; benzene;
DOI:10.1021/jo00217a017
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 73 percent / NaH / dimethylformamide / Ambient temperature
2: 56 percent / 3-chloroperbenzoic acid (MCBA) / CH2Cl2 / 15 h / 4 - 20 °C
3: 87 percent / sodium azide, ammonium chloride / ethanol; H2O / 16 h / Heating
4: hydrogen / 5percent Pd/C / ethanol / 16 h
5: 75 percent / triethylamine / diethyl ether; tetrahydrofuran / 0.17 h
6: 80 percent / SOCl2 / 2 h / 40 °C
7: 85 percent / 5N HCl / various solvent(s) / 24 h / Heating
With
hydrogenchloride; thionyl chloride; sodium azide; ammonium chloride; hydrogen; sodium hydride; triethylamine; 3-chloro-benzenecarboperoxoic acid;
palladium on activated charcoal;
In
tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jo00217a017
