(S)-2-[(3S,7S)-3-((S)-2-Acetylsulfanyl-3-phenyl-propionylamino)-2-oxo-7-propyl-azepan-1-yl]-butyric acid methyl ester

Base Information

Chemical Name:(S)-2-[(3S,7S)-3-((S)-2-Acetylsulfanyl-3-phenyl-propionylamino)-2-oxo-7-propyl-azepan-1-yl]-butyric acid methyl ester
CAS No.:1027542-31-9
Molecular Formula:C₂₅H₃₆N₂O₅S
Molecular Weight:476.637
Hs Code.:

Synonyms:(S)-2-[(3S,7S)-3-((S)-2-Acetylsulfanyl-3-phenyl-propionylamino)-2-oxo-7-propyl-azepan-1-yl]-butyric acid methyl ester

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Chemical Property of (S)-2-[(3S,7S)-3-((S)-2-Acetylsulfanyl-3-phenyl-propionylamino)-2-oxo-7-propyl-azepan-1-yl]-butyric acid methyl ester

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Technology Process of (S)-2-[(3S,7S)-3-((S)-2-Acetylsulfanyl-3-phenyl-propionylamino)-2-oxo-7-propyl-azepan-1-yl]-butyric acid methyl ester

There total 8 articles about (S)-2-[(3S,7S)-3-((S)-2-Acetylsulfanyl-3-phenyl-propionylamino)-2-oxo-7-propyl-azepan-1-yl]-butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 84688-11-9
(S)-2-(1,3-dioxoisoindolin-2-yl)-6-hydroxyhexanoic acid

: 1027542-31-9
(S)-2-[(3S,7S)-3-((S)-2-Acetylsulfanyl-3-phenyl-propionylamino)-2-oxo-7-propyl-azepan-1-yl]-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 94 percent / 4-methylmorpholine, 1-hydroxybenzotriazole hydrate, 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / dimethylformamide / 1.) 0 deg C, 1 h, 2.) RT, 2 h

2: 1.) DMSO, oxalyl chloride, 2.) TEA / 1.) CH₂Cl₂, -78 deg C, 15 min, 2.) CH₂Cl₂, from -78 deg C to 0 deg C

3: TFA / CHCl₃ / 144 h / Heating

4: 319 mg / TiCl₄ / CH₂Cl₂ / 28 h

5: diethyl ether; methanol; CH₂Cl₂ / 0.17 h / 0 °C

6: 95 percent / H₂ / 10percent Pd/C / ethyl acetate / 3.5 h / Ambient temperature

7: hydrazine monohydrate / methanol / 48 h / Ambient temperature

8: TEA, (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / CH₂Cl₂ / 1.) 0 deg C, 1 h, 2.) RT, 2 h

With 4-methyl-morpholine; oxalyl dichloride; TEA; hydrogen; titanium tetrachloride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; hydrazine hydrate; dimethyl sulfoxide; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; palladium on activated charcoal; In methanol; diethyl ether; dichloromethane; chloroform; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm950677a

Reference yield:

: 171900-74-6
(S)-2-[(S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-6-hydroxy-hexanoylamino]-butyric acid ethyl ester

: 1027542-31-9
(S)-2-[(3S,7S)-3-((S)-2-Acetylsulfanyl-3-phenyl-propionylamino)-2-oxo-7-propyl-azepan-1-yl]-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) DMSO, oxalyl chloride, 2.) TEA / 1.) CH₂Cl₂, -78 deg C, 15 min, 2.) CH₂Cl₂, from -78 deg C to 0 deg C

2: TFA / CHCl₃ / 144 h / Heating

3: 319 mg / TiCl₄ / CH₂Cl₂ / 28 h

4: diethyl ether; methanol; CH₂Cl₂ / 0.17 h / 0 °C

5: 95 percent / H₂ / 10percent Pd/C / ethyl acetate / 3.5 h / Ambient temperature

6: hydrazine monohydrate / methanol / 48 h / Ambient temperature

7: TEA, (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / CH₂Cl₂ / 1.) 0 deg C, 1 h, 2.) RT, 2 h

With oxalyl dichloride; TEA; hydrogen; titanium tetrachloride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; hydrazine hydrate; dimethyl sulfoxide; trifluoroacetic acid; palladium on activated charcoal; In methanol; diethyl ether; dichloromethane; chloroform; ethyl acetate;
DOI:10.1021/jm950677a

Reference yield:

: 171900-75-7
<3S-(1R*,3α,7β)>-hexahydro-α-ethyl-2-oxo-3-phthalimido-7-(2-propenyl)-1H-azepine-1-acetic acid

: 1027542-31-9
(S)-2-[(3S,7S)-3-((S)-2-Acetylsulfanyl-3-phenyl-propionylamino)-2-oxo-7-propyl-azepan-1-yl]-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: diethyl ether; methanol; CH₂Cl₂ / 0.17 h / 0 °C

2: 95 percent / H₂ / 10percent Pd/C / ethyl acetate / 3.5 h / Ambient temperature

3: hydrazine monohydrate / methanol / 48 h / Ambient temperature

4: TEA, (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / CH₂Cl₂ / 1.) 0 deg C, 1 h, 2.) RT, 2 h

With TEA; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; hydrazine hydrate; palladium on activated charcoal; In methanol; diethyl ether; dichloromethane; ethyl acetate;
DOI:10.1021/jm950677a