2,5-Dichlorothiophene

Base Information

• Chemical Name: 2,5-Dichlorothiophene
• CAS No.: 173777-89-4
• Molecular Formula: C₄H₂Cl₂S
• Molecular Weight: 153.032
• Mol file: 173777-89-4.mol

Synonyms:DICHLOROTHIOPHENE;2,6-DICHLOROTHIOPHENE;2,5-Dichlorothiophene, 96.0%(GC)

Chemical Property of 2,5-Dichlorothiophene

Chemical Property:

• Vapor Pressure: 3.33mmHg at 25°C
• Refractive Index: 1.584
• Boiling Point: 158.9 °C at 760 mmHg
• Flash Point: 59.4 °C
• PSA: 28.24000
• Density: 1.488 g/cm³
• LogP: 3.05490

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s): R26/27/28:; R40:
• Hazard Codes: T+:Very toxic
• Statements: R26/27/28:; R40:
• Safety Statements: S28A:; S36/37:; S45:

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,5-Dichlorothiophene

There total 18 articles about 2,5-Dichlorothiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

thiophene (188290-36-0,8014-23-1,25233-34-5) → 2,5-diclorothiophene (3172-52-9,173777-89-4)

Guidance literature:

With N-chloro-succinimide; In tetrachloromethane; for 4h; Time; Reflux;

Reference yield: 82.0%

2-thienyl chloride (96-43-5) → 2,5-diclorothiophene (3172-52-9,173777-89-4)

Guidance literature:

With N-chloro-succinimide; perchloric acid; In tetrachloromethane; for 24h; Ambient temperature;

DOI:10.1021/jo00063a028

Reference yield: 59.0%

thiophene (188290-36-0,8014-23-1,25233-34-5) → 2-thienyl chloride (96-43-5) + 2,5-diclorothiophene (3172-52-9,173777-89-4)

Guidance literature:

With ammonium nitrate; N-chloro-succinimide; In acetonitrile; for 1h;

DOI:10.1246/cl.2003.932

upstream raw materials:

thiophene

N-chloroacetamide

2-thienyl chloride

2-thiophenylcarboxylic acid

Downstream raw materials:

2-tert.Butoxy-5-chlorthiophen

2,5-dichlorothiophene-4-carboxaldehyde

phenyl N-(2,5,5-trichloro-2,5-dihydro-2-thienyl)-carbamate

phenyl N-(3,5-dichloro-2-thienyl)-carbamate

Refernces

• 1、 Bunnett et al.. "-". . p. 1493. Retrieved 1949.
• 2、 Cornella, Josep,Lahlali, Hicham,Larrosa, Igor. "Decarboxylative homocoupling of (hetero)aromatic carboxylic acids". supporting information; experimental part. p. 8276 - 8278. Retrieved 2010/12/19.