1,1-dimethylethyl 3-{[({(1S,3S)-3-[(6-cyano-1H-benzimidazol-1-yl)methyl]-1-hydroxycyclohexaneyl}methyl)amino]methyl}-3-methyl-1-pyrrolidinecarboxylate

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Chemical Name:1,1-dimethylethyl 3-{[({(1S,3S)-3-[(6-cyano-1H-benzimidazol-1-yl)methyl]-1-hydroxycyclohexaneyl}methyl)amino]methyl}-3-methyl-1-pyrrolidinecarboxylate
CAS No.:1416324-40-7
Molecular Formula:C₂₇H₃₉N₅O₃
Molecular Weight:481.638
Hs Code.:

1,1-dimethylethyl 3-{[({(1S,3S)-3-[(6-cyano-1H-benzimidazol-1-yl)methyl]-1-hydroxycyclohexaneyl}methyl)amino]methyl}-3-methyl-1-pyrrolidinecarboxylate

Synonyms:1,1-dimethylethyl 3-{[({(1S,3S)-3-[(6-cyano-1H-benzimidazol-1-yl)methyl]-1-hydroxycyclohexaneyl}methyl)amino]methyl}-3-methyl-1-pyrrolidinecarboxylate

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Chemical Property of 1,1-dimethylethyl 3-{[({(1S,3S)-3-[(6-cyano-1H-benzimidazol-1-yl)methyl]-1-hydroxycyclohexaneyl}methyl)amino]methyl}-3-methyl-1-pyrrolidinecarboxylate

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Technology Process of 1,1-dimethylethyl 3-{[({(1S,3S)-3-[(6-cyano-1H-benzimidazol-1-yl)methyl]-1-hydroxycyclohexaneyl}methyl)amino]methyl}-3-methyl-1-pyrrolidinecarboxylate

There total 8 articles about 1,1-dimethylethyl 3-{[({(1S,3S)-3-[(6-cyano-1H-benzimidazol-1-yl)methyl]-1-hydroxycyclohexaneyl}methyl)amino]methyl}-3-methyl-1-pyrrolidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.4%

: 1158758-67-8
1,1-dimethylethyl 3-(aminomethyl)-3-methyl-1-pyrrolidinecarboxylate

: 1416324-38-3
1-[(3S,5S)-1-oxaspiro[2.5]oct-5-ylmethyl]-1H-benzimidazole-6-carbonitrile

: 1416324-40-7
1,1-dimethylethyl 3-{[({(1S,3S)-3-[(6-cyano-1H-benzimidazol-1-yl)methyl]-1-hydroxycyclohexaneyl}methyl)amino]methyl}-3-methyl-1-pyrrolidinecarboxylate

Guidance literature:: In isopropyl alcohol; at 102 ℃;

Reference yield:

: 136658-31-6
(S)-(1l,2u,4'u,5'u)-4',5'-Diphenylspiroheptane-2,2'-<1,3>dioxolane>

: 1416324-40-7
1,1-dimethylethyl 3-{[({(1S,3S)-3-[(6-cyano-1H-benzimidazol-1-yl)methyl]-1-hydroxycyclohexaneyl}methyl)amino]methyl}-3-methyl-1-pyrrolidinecarboxylate

Guidance literature:: Multi-step reaction with 8 steps

1.1: hydrogen bromide / water; methanol / 18 h / 20 °C

2.1: N,N-dimethyl-formamide / 24 h / 80 °C

3.1: hydrazine / methanol / 2 h / Reflux

4.1: potassium carbonate / dichloromethane; acetonitrile / 120 h / 20 °C

5.1: formic acid; iron / ethyl acetate; methanol / 3 h / 64 °C

6.1: formic acid / 70 °C

7.1: potassium tert-butylate / dimethyl sulfoxide / 1 h / 20 °C / Inert atmosphere

7.2: Inert atmosphere

8.1: isopropyl alcohol / 102 °C

With formic acid; potassium tert-butylate; hydrogen bromide; iron; potassium carbonate; hydrazine; In methanol; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;

Reference yield:

: 1416324-33-8
(2R,3R,7S)-7-(bromomethyl)-2,3-diphenyl-1,4-dioxaspiro[4.5]decane

: 1416324-40-7
1,1-dimethylethyl 3-{[({(1S,3S)-3-[(6-cyano-1H-benzimidazol-1-yl)methyl]-1-hydroxycyclohexaneyl}methyl)amino]methyl}-3-methyl-1-pyrrolidinecarboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: N,N-dimethyl-formamide / 24 h / 80 °C

2.1: hydrazine / methanol / 2 h / Reflux

3.1: potassium carbonate / dichloromethane; acetonitrile / 120 h / 20 °C

4.1: formic acid; iron / ethyl acetate; methanol / 3 h / 64 °C

5.1: formic acid / 70 °C

6.1: potassium tert-butylate / dimethyl sulfoxide / 1 h / 20 °C / Inert atmosphere

6.2: Inert atmosphere

7.1: isopropyl alcohol / 102 °C

With formic acid; potassium tert-butylate; iron; potassium carbonate; hydrazine; In methanol; dichloromethane; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;