benzyloxycarbonylseryl-asparagine 4-nitrobenzyl ester

Base Information

Chemical Name:benzyloxycarbonylseryl-asparagine 4-nitrobenzyl ester
CAS No.:110523-36-9
Molecular Formula:C₂₂H₂₄N₄O₉
Molecular Weight:488.454
Hs Code.:

Synonyms:benzyloxycarbonylseryl-asparagine 4-nitrobenzyl ester

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Chemical Property of benzyloxycarbonylseryl-asparagine 4-nitrobenzyl ester

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Technology Process of benzyloxycarbonylseryl-asparagine 4-nitrobenzyl ester

There total 1 articles about benzyloxycarbonylseryl-asparagine 4-nitrobenzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1145-80-8
N-(benzyloxycarbonyl)-L-serine

: 37788-09-3
asparagine 4-nitrobenzyl ester

: 110523-36-9
benzyloxycarbonylseryl-asparagine 4-nitrobenzyl ester

Guidance literature:: With 1-ethyl-piperidine; chloroformic acid ethyl ester; Yield given. Multistep reaction; 1) dimethylformamide, -10 deg C, 10 min, 2) 0 deg C, 30 min, then room temperature, 2 h;

Reference yield: 95.0%

: 110523-36-9
benzyloxycarbonylseryl-asparagine 4-nitrobenzyl ester

: 110523-37-0
seryl-asparagine 4-nitrobenzyl ester hydrobromide

Guidance literature:: With hydrogen bromide; In acetic acid; for 1h; Ambient temperature;

Reference yield:

: 110523-36-9
benzyloxycarbonylseryl-asparagine 4-nitrobenzyl ester

: 63958-90-7
pyroglutamyl-alanyl-lysyl-seryl-glutaminyl-glycyl-glycyl-seryl-asparagine

Guidance literature:: Multi-step reaction with 9 steps

1: 95 percent / hydrogen bromide / acetic acid / 1 h / Ambient temperature

2: 40 percent / triethylamine, N,N'-dicyclohexylcarbodiimide / dimethylformamide / 1) O deg C, 2 h, 2) room temperature, 8 h

3: 96 percent / hydrochloric acid / acetic acid; H₂O / 1 h / Ambient temperature

4: 1) N-ethylpiperidine, ethyl chloroformate / 1) dimethylformamide, -10 deg C, 10 min, 2) 0 deg C, 30 min, then room temperature, 2h

5: 90 percent / hydrogen bromide / acetic acid / 1 h / Ambient temperature

6: 1) triethylamine, 1-hydroxybenztriazole, N,N'-dicyclohexylcarbodiimide / 1) dimethylformamide, -10 deg C, 10 min, 2) 0 deg C, 2 h, room temperature, 8 h

7: 93 percent / hydrogen chloride / acetic acid; H₂O / 0.75 h / Ambient temperature

8: 1) 1-hydroxybenztriazole, N,N'-dicyclohexylcarbodiimide 2) N-ethylpiperidine / 1) dimethylformamide, -10 deg C, 10 min, 2) 0 deg C, 2 h, then room temperature, 8 h

9: 84 percent / H₂ / Pd-black / acetic acid; H₂O / 12 h / Ambient temperature

With 1-ethyl-piperidine; hydrogenchloride; hydrogen bromide; hydrogen; chloroformic acid ethyl ester; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; palladium; In water; acetic acid; N,N-dimethyl-formamide;