1-Boc-1,8-diaminooctane

Base Information

• Chemical Name: 1-Boc-1,8-diaminooctane
• CAS No.: 88829-82-7
• Molecular Formula: C13H28N2O2
• Molecular Weight: 244.378
• Hs Code.: 2924199090
• Mol file: 88829-82-7.mol

Synonyms:Carbamicacid, (8-aminooctyl)-, 1,1-dimethylethyl ester (9CI);Boc-1,8-diaminooctane;tert-Butyl (8-aminooctyl)carbamate;

Chemical Property of 1-Boc-1,8-diaminooctane

Chemical Property:

• Vapor Pressure: 2.96E-05mmHg at 25°C
• Refractive Index: 1.461
• Boiling Point: 356.3 °C at 760 mmHg
• Flash Point: 169.3 °C
• PSA: 64.35000
• Density: 0.942 g/cm³
• LogP: 3.90160
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Solubility.: Chloroform, Methanol

Purity/Quality:

99%, ^*data from raw suppliers

1-Boc-1,8-diaminooctane ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Description: tert-butyl (8-aminooctyl)carbamate can be used as a PROTAC linker in the synthesis of PROTACs. tert-butyl (8-aminooctyl)carbamate is an alkane chain with terminal amine and Boc-protected amino groups. Amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The Boc group can be deprotected under mild acidic conditions to form the free amine.

Technology Process of 1-Boc-1,8-diaminooctane

There total 15 articles about 1-Boc-1,8-diaminooctane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

→ tert-butyl N-(8-aminooctyl)carbamate (88829-82-7)

Guidance literature:

Reference yield: 99.0%

tert-butyl N-{8-[(trifluoroacetyl)amino]octyl}carbamate (556065-56-6) → tert-butyl N-(8-aminooctyl)carbamate (88829-82-7)

Guidance literature:

With ammonium hydroxide; In methanol; for 48h; Heating;

DOI:10.1016/S0031-9422(03)00133-X

Reference yield: 97.0%

1,8-diaminooctan (373-44-4) + di-tert-butyl dicarbonate (24424-99-5) → tert-butyl N-(8-aminooctyl)carbamate (88829-82-7)

Guidance literature:

In chloroform; at 20 ℃; for 44h; Inert atmosphere;

DOI:10.1039/c7cc03043f

upstream raw materials:

N-(tert-butyloxycarbonyl) azide

1,8-diaminooctan

di-tert-butyl dicarbonate

N,N'-bis(t-butoxycarbonyl)-1,8-octanediamine

Downstream raw materials:

Fmoc-Tyr(O-Pic)-NH-(CH₂)8-NH-Boc

4-[(1E)-3-({8-[(tert-butoxycarbonyl)amino]octyl}amino)-3-oxoprop-1-enyl]phenyl acetate

tert-butyl [8-(1-phenethylpiperidin-4-ylamino)octyl]carbamate

N-(8-amino-octyl)-N-(1-phenethyl-piperidin-4-yl)-propionamide