(3R,5S)-5-acetoxy-2-benzyl-3-[(2S,4R,5R)-5-(tert-butyldimethylsiloxy)-2-methyl-1,3-dioxan-4-yl]isoxazolidine

Base Information

Chemical Name:(3R,5S)-5-acetoxy-2-benzyl-3-[(2S,4R,5R)-5-(tert-butyldimethylsiloxy)-2-methyl-1,3-dioxan-4-yl]isoxazolidine
CAS No.:1035422-90-2
Molecular Formula:C₂₃H₃₇NO₆Si
Molecular Weight:451.635
Hs Code.:

Synonyms:(3R,5S)-5-acetoxy-2-benzyl-3-[(2S,4R,5R)-5-(tert-butyldimethylsiloxy)-2-methyl-1,3-dioxan-4-yl]isoxazolidine

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Chemical Property of (3R,5S)-5-acetoxy-2-benzyl-3-[(2S,4R,5R)-5-(tert-butyldimethylsiloxy)-2-methyl-1,3-dioxan-4-yl]isoxazolidine

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Technology Process of (3R,5S)-5-acetoxy-2-benzyl-3-[(2S,4R,5R)-5-(tert-butyldimethylsiloxy)-2-methyl-1,3-dioxan-4-yl]isoxazolidine

There total 1 articles about (3R,5S)-5-acetoxy-2-benzyl-3-[(2S,4R,5R)-5-(tert-butyldimethylsiloxy)-2-methyl-1,3-dioxan-4-yl]isoxazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 108-05-4,9003-20-7
vinyl acetate

: 221351-89-9
C₁₉H₃₁NO₄Si

: 1035422-92-4
(3R,5R)-5-acetoxy-2-benzyl-3-[(2S,4R,5R)-5-(tert-butyldimethylsiloxy)-2-methyl-1,3-dioxan-4-yl]isoxazolidine

: 1035422-90-2
(3R,5S)-5-acetoxy-2-benzyl-3-[(2S,4R,5R)-5-(tert-butyldimethylsiloxy)-2-methyl-1,3-dioxan-4-yl]isoxazolidine

Guidance literature:: for 24h; Heating;
DOI:10.1055/s-2008-1042942

Reference yield: 67.0%

: 1035422-90-2
(3R,5S)-5-acetoxy-2-benzyl-3-[(2S,4R,5R)-5-(tert-butyldimethylsiloxy)-2-methyl-1,3-dioxan-4-yl]isoxazolidine

: 66-22-8,144104-68-7,18324-22-6,27072-01-1,2920-92-5,51953-19-6
uracil

: 1-{(3R,5R)-2-benzyl-3-[(2S,4R,5R)-5-(tert-butyldimethylsiloxy)-2-methyl-1,3-dioxan-4-yl]isoxazolidin-5-yl}pyrimidine-2,4(1H,3H)-dione

: 1035423-02-9
1-{(3R,5S)-2-benzyl-3-[(2S,4R,5R)-5-(tert-butyldimethylsiloxy)-2-methyl-1,3-dioxan-4-yl]isoxazolidin-5-yl}pyrimidine-2,4(1H,3H)-dione

Guidance literature:: uracil; With N,O-bis-(trimethylsilyl)-acetamide; In dichloromethane; for 0.333333h; Heating;

(3R,5S)-5-acetoxy-2-benzyl-3-[(2S,4R,5R)-5-(tert-butyldimethylsiloxy)-2-methyl-1,3-dioxan-4-yl]isoxazolidine; With trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at 20 ℃; for 2h; Further stages.;
DOI:10.1055/s-2008-1042942

Reference yield: 51.0%

: 1035422-90-2
(3R,5S)-5-acetoxy-2-benzyl-3-[(2S,4R,5R)-5-(tert-butyldimethylsiloxy)-2-methyl-1,3-dioxan-4-yl]isoxazolidine

: 65-71-4,28806-14-6,691841-57-3
thymin

: 1035423-06-3
1-{(3R,5R)-2-benzyl-3-[(2S,4R,5R)-5-(tert-butyldimethylsiloxy)-2-methyl-1,3-dioxan-4-yl]isoxazolidin-5-yl}-5-methylpyrimidine-2,4(1H,3H)-dione

: 1035423-04-1
1-{(3R,5S)-2-benzyl-3-[(2S,4R,5R)-5-(tert-butyldimethylsiloxy)-2-methyl-1,3-dioxan-4-yl]isoxazolidin-5-yl}-5-methylpyrimidine-2,4(1H,3H)-dione

Guidance literature:: thymin; With N,O-bis-(trimethylsilyl)-acetamide; In dichloromethane; for 0.333333h; Heating;

(3R,5S)-5-acetoxy-2-benzyl-3-[(2S,4R,5R)-5-(tert-butyldimethylsiloxy)-2-methyl-1,3-dioxan-4-yl]isoxazolidine; With trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at 20 ℃; for 2h; Further stages.;
DOI:10.1055/s-2008-1042942