3-(4-CHLORO-2-NITROPHENYL) METHYL ACRYLATE

Base Information

• Chemical Name: 3-(4-CHLORO-2-NITROPHENYL) METHYL ACRYLATE
• CAS No.: 150869-41-3
• Molecular Formula: C10H8 Cl N O4
• Molecular Weight: 241.631
• Mol file: 150869-41-3.mol

Synonyms:2-Propenoicacid, 3-(4-chloro-2-nitrophenyl)-, methyl ester, (E)-

Chemical Property of 3-(4-CHLORO-2-NITROPHENYL) METHYL ACRYLATE

Chemical Property:

• Boiling Point: 368.3±32.0 °C(Predicted)
• PSA: 72.12000
• Density: 1.387±0.06 g/cm3(Predicted)
• LogP: 2.95760

Purity/Quality:

98%Min ^*data from raw suppliers

3-(4-CHLORO-2-NITROPHENYL) METHYL ACRYLATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(4-CHLORO-2-NITROPHENYL) METHYL ACRYLATE

There total 2 articles about 3-(4-CHLORO-2-NITROPHENYL) METHYL ACRYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-Chloro-2-nitrobenzaldehyde (5551-11-1) + methyl (triphenylphosphoranylidene)acetate (21204-67-1,2605-67-6) → methyl (E)-3-(4-chloro-2-nitrophenyl)acrylate (150869-41-3)

Guidance literature:

In toluene; for 1h; Heating;

Reference yield: 33.0%

Methyl diethylphosphonoacetate (1067-74-9) + 4-Chloro-2-nitrobenzaldehyde (5551-11-1) → methyl (E)-3-(4-chloro-2-nitrophenyl)acrylate (150869-41-3)

Guidance literature:

Methyl diethylphosphonoacetate; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

4-Chloro-2-nitrobenzaldehyde; In N,N-dimethyl-formamide; at 20 ℃; for 3h; Further stages.;

DOI:10.1016/j.bmcl.2007.09.103

Reference yield: 71.0%

methyl (E)-3-(4-chloro-2-nitrophenyl)acrylate (150869-41-3) → methyl trans-4-chloro-2-aminocinnamate (150869-42-4)

Guidance literature:

With acetic acid; zinc; In ethanol; at 60 ℃; for 4h;

upstream raw materials:

4-Chloro-2-nitrobenzaldehyde

methyl (triphenylphosphoranylidene)acetate

Methyl diethylphosphonoacetate

Downstream raw materials:

methyl trans-4-chloro-2-aminocinnamate

(E)-3-(2-amino-4-chlorophenyl)-acrylic acid

(E)-3-(2-amino-4-chlorophenyl)-1-[(R)-4-(4-fluorobenzyl)-2-methylpiperazin-1-yl]-propenone

C₂₇H₂₇ClN₃FO₄