α-(tert-Butyloxycarbonylamino)isobutyric acid pentachlorophenyl ester

Base Information

• Chemical Name: α-(tert-Butyloxycarbonylamino)isobutyric acid pentachlorophenyl ester
• CAS No.: 84758-58-7
• Molecular Formula: C₁₅H₁₆Cl₅NO₄
• Molecular Weight: 451.561
• Mol file: 84758-58-7.mol

Synonyms:α-(tert-Butyloxycarbonylamino)isobutyric acid pentachlorophenyl ester

Chemical Property of α-(tert-Butyloxycarbonylamino)isobutyric acid pentachlorophenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of α-(tert-Butyloxycarbonylamino)isobutyric acid pentachlorophenyl ester

There total 6 articles about α-(tert-Butyloxycarbonylamino)isobutyric acid pentachlorophenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

Pentachlorophenol (87-86-5,67471-28-7) + Boc-Aib-OH (30992-29-1) → α-(tert-Butyloxycarbonylamino)isobutyric acid pentachlorophenyl ester (84758-58-7)

Guidance literature:

With dicyclohexyl-carbodiimide; In ethyl acetate;

DOI:10.1016/0040-4020(82)85164-8

Reference yield:

N-(tert-butyloxycarbonyl) azide (1070-19-5) → α-(tert-Butyloxycarbonylamino)isobutyric acid pentachlorophenyl ester (84758-58-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 45 percent

2: 75 percent / DCC / ethyl acetate

With dicyclohexyl-carbodiimide; In ethyl acetate;

DOI:10.1016/0040-4020(82)85164-8

Reference yield:

tert-butoxycarbonylamino-2-methyl-propionic acid benzyl ester (84758-57-6) → α-(tert-Butyloxycarbonylamino)isobutyric acid pentachlorophenyl ester (84758-58-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / H₂ / Pd/C

2: 75 percent / DCC / ethyl acetate

With hydrogen; dicyclohexyl-carbodiimide; palladium on activated charcoal; In ethyl acetate;

DOI:10.1016/0040-4020(82)85164-8

upstream raw materials:

Pentachlorophenol

Boc-Aib-OH

N-(tert-butyloxycarbonyl) azide

N-(tert-butoxycarbonyl)-α-methylalanine methyl ester