ethyl (2S,3R,4S)-1-(4-tolylsulfonyl)-3-methyl-4-hydroxy-2-hydroxymethylpyrrolidine

Base Information

Chemical Name:ethyl (2S,3R,4S)-1-(4-tolylsulfonyl)-3-methyl-4-hydroxy-2-hydroxymethylpyrrolidine
CAS No.:152955-41-4
Molecular Formula:C₁₃H₁₉NO₄S
Molecular Weight:285.364
Hs Code.:

Synonyms:ethyl (2S,3R,4S)-1-(4-tolylsulfonyl)-3-methyl-4-hydroxy-2-hydroxymethylpyrrolidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl (2S,3R,4S)-1-(4-tolylsulfonyl)-3-methyl-4-hydroxy-2-hydroxymethylpyrrolidine

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Technology Process of ethyl (2S,3R,4S)-1-(4-tolylsulfonyl)-3-methyl-4-hydroxy-2-hydroxymethylpyrrolidine

There total 1 articles about ethyl (2S,3R,4S)-1-(4-tolylsulfonyl)-3-methyl-4-hydroxy-2-hydroxymethylpyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

: (3R,4S)-1-(4-toluenesulfonyl)-3-methyl-4-hydroxy-2-pyrrolidinecarboxylic acid ethyl ester

: 152955-41-4
ethyl (2S,3R,4S)-1-(4-tolylsulfonyl)-3-methyl-4-hydroxy-2-hydroxymethylpyrrolidine

: 152955-42-5
ethyl (2R,3R,4S)-1-(4-tolylsulfonyl)-3-methyl-4-hydroxy-2-hydroxymethylpyrrolidine

Guidance literature:: With lithium borohydride; In tetrahydrofuran; at 0 - 20 ℃; for 4h;
DOI:10.1002/jhet.5570300241

Reference yield: 93.0%

: 98-59-9
p-toluenesulfonyl chloride

: 152955-41-4
ethyl (2S,3R,4S)-1-(4-tolylsulfonyl)-3-methyl-4-hydroxy-2-hydroxymethylpyrrolidine

: 152955-43-6
(2S,3R,4S)-1-(4-toluenesulfonyl)-2-(4-toluenesulfonyloxymethyl)-3-methyl-4-(4-toluenesulfonyloxy)pyrrolidine

Guidance literature:: With pyridine; Ambient temperature;
DOI:10.1002/jhet.5570300241 DOI:10.1016/0223-5234(93)90013-5

Reference yield:

: 152955-41-4
ethyl (2S,3R,4S)-1-(4-tolylsulfonyl)-3-methyl-4-hydroxy-2-hydroxymethylpyrrolidine

: 152955-45-8
(1S,4S,7S)-2-(4-toluenesulfonyl)-5-phenylmethyl-7-methyl-2,5-diazabicyclo<2.2.1>heptane

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / pyridine / Ambient temperature

2: 51 percent / o-xylene / 25 h / Heating

With pyridine; In o-xylene;
DOI:10.1002/jhet.5570300241 DOI:10.1016/0223-5234(93)90013-5