[1-[(1-Methylpyrrolidin-2-yl)methyl]pyrrolidin-2-yl]methanol

Base Information

Chemical Name:[1-[(1-Methylpyrrolidin-2-yl)methyl]pyrrolidin-2-yl]methanol
CAS No.:66283-23-6
Molecular Formula:C₁₁H₂₂N₂O
Molecular Weight:198.308
Hs Code.:2933990090
DSSTox Substance ID:DTXSID90402332,DTXSID101195465
Mol file:66283-23-6.mol

Synonyms:[1-[(1-methylpyrrolidin-2-yl)methyl]pyrrolidin-2-yl]methanol;66283-23-6;387362-69-8;{1-[(1-methylpyrrolidin-2-yl)methyl]pyrrolidin-2-yl}methan-1-ol;{1-[(1-methylpyrrolidin-2-yl)methyl]pyrrolidin-2-yl}methanol;2-Pyrrolidinemethanol, 1-[(1-methyl-2-pyrrolidinyl)methyl]-;(2S,2'S)-(-)-2-Hydroxymethyl-1-[(1-methylpyrrolidin-2-yl)-methyl]-pyrrolidine;ST51005998;Oprea1_205085;SCHEMBL5010748;DTXSID90402332;DTXSID101195465;AKOS024370396;1-[(1-Methyl-2-pyrrolidinyl)methyl]-2-pyrrolidinemethanol;(2S,2S)-(-)-2-HYDROXYMETHYL-1-[(1-METHYLPYRROLIDIN-2-YL)-METHYL]-PYRROLIDINE

Suppliers and Price of [1-[(1-Methylpyrrolidin-2-yl)methyl]pyrrolidin-2-yl]methanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Labseeker
(2S,2'S)-(-)-2-Hydroxymethyl-1-[(1-methylpyrrolidin-2-yl)-methyl]-pyrrolidine 95
5g
$ 1150.00

American Custom Chemicals Corporation
(2S,2'S)-(-)-2-HYDROXYMETHYL-1-[(1-METHYLPYRROLIDIN-2-YL)-METHYL]-PYRROLIDINE 95.00%
5MG
$ 501.06

Total 7 raw suppliers

Chemical Property of [1-[(1-Methylpyrrolidin-2-yl)methyl]pyrrolidin-2-yl]methanol

Chemical Property:

Refractive Index:n20/D 1.494
Boiling Point:275-277 °C
PSA：26.71000
LogP:0.41310
XLogP3:0.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:198.173213330
Heavy Atom Count:14
Complexity:186

Purity/Quality:

99% ^*data from raw suppliers

(2S,2'S)-(-)-2-Hydroxymethyl-1-[(1-methylpyrrolidin-2-yl)-methyl]-pyrrolidine 95 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:C
Statements: 34
Safety Statements: 26-36/37/39-45

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1CCCC1CN2CCCC2CO

Technology Process of [1-[(1-Methylpyrrolidin-2-yl)methyl]pyrrolidin-2-yl]methanol

There total 5 articles about [1-[(1-Methylpyrrolidin-2-yl)methyl]pyrrolidin-2-yl]methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 17708-83-7
(S)-benzyl 2-((S)-2-(methoxycarbonyl)pyrrolidine-1-carbonyl)pyrrolidine-1-carboxylate

: 66283-23-6
(2S,2'S)-2-hydroxymethyl-1-<(1-methylpyrrolidine-2-yl)methyl>pyrrolidine

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; for 3h; Heating;
DOI:10.1016/S0040-4020(01)93286-7

Reference yield:

: 147-85-3,25191-13-3,37159-97-0,4305-67-3,4607-28-7
L-proline

: 66283-23-6
(2S,2'S)-2-hydroxymethyl-1-<(1-methylpyrrolidine-2-yl)methyl>pyrrolidine

Guidance literature:: Multi-step reaction with 3 steps

1: NaHCO₃

2: 92 percent / dicyclohexylcarbodiimide / CHCl₃ / 0 degC, 3 h and RT, overnight

3: 81 percent / LiAlH₄ / tetrahydrofuran / 3 h / Heating

With lithium aluminium tetrahydride; sodium hydrogencarbonate; dicyclohexyl-carbodiimide; In tetrahydrofuran; chloroform;
DOI:10.1016/S0040-4020(01)93286-7

Reference yield:

: 1148-11-4
N-Benzyloxycarbonyl-L-proline

: 66283-23-6
(2S,2'S)-2-hydroxymethyl-1-<(1-methylpyrrolidine-2-yl)methyl>pyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / dicyclohexylcarbodiimide / CHCl₃ / 0 degC, 3 h and RT, overnight

2: 81 percent / LiAlH₄ / tetrahydrofuran / 3 h / Heating

With lithium aluminium tetrahydride; dicyclohexyl-carbodiimide; In tetrahydrofuran; chloroform;
DOI:10.1016/S0040-4020(01)93286-7