7-chloro-1-methyl-5-(2-trifluoromethyl-phenyl)-1,3-dihydro-thieno[2,3-e][1,4]diazepin-2-one

Base Information

Chemical Name:7-chloro-1-methyl-5-(2-trifluoromethyl-phenyl)-1,3-dihydro-thieno[2,3-e][1,4]diazepin-2-one
CAS No.:40018-16-4
Molecular Formula:C₁₅H₁₀ClF₃N₂OS
Molecular Weight:358.771
Hs Code.:

7-chloro-1-methyl-5-(2-trifluoromethyl-phenyl)-1,3-dihydro-thieno[2,3-<i>e</i>][1,4]diazepin-2-one

Synonyms:7-chloro-1-methyl-5-(2-trifluoromethyl-phenyl)-1,3-dihydro-thieno[2,3-e][1,4]diazepin-2-one

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Chemical Property of 7-chloro-1-methyl-5-(2-trifluoromethyl-phenyl)-1,3-dihydro-thieno[2,3-e][1,4]diazepin-2-one

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Technology Process of 7-chloro-1-methyl-5-(2-trifluoromethyl-phenyl)-1,3-dihydro-thieno[2,3-e][1,4]diazepin-2-one

There total 10 articles about 7-chloro-1-methyl-5-(2-trifluoromethyl-phenyl)-1,3-dihydro-thieno[2,3-e][1,4]diazepin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 40018-17-5
1-methyl-5-(2-trifluoromethyl-phenyl)-1,3-dihydro-thieno[2,3-e][1,4]diazepin-2-one

: 40018-16-4
7-chloro-1-methyl-5-(2-trifluoromethyl-phenyl)-1,3-dihydro-thieno[2,3-e][1,4]diazepin-2-one

Guidance literature:: With sulfuryl dichloride; In acetic acid; for 4h; Ambient temperature;
DOI:10.1002/ardp.19803130704

Reference yield:

: 447-60-9
2-(trifluoromethyl)benzonitrile

: 40018-16-4
7-chloro-1-methyl-5-(2-trifluoromethyl-phenyl)-1,3-dihydro-thieno[2,3-e][1,4]diazepin-2-one

Guidance literature:: Multi-step reaction with 9 steps

1: 29 percent / Na / benzene / Heating; 1.) 4 h, reflux, 2.) 12 h, room temp.

2: 88 percent / conc. aq. HCl

3: 78 percent / Et₃N / dioxane / 0.5 h / Heating

4: K₂CO₃ / dioxane / 2 h / Ambient temperature

5: NaI / acetone / 1 h / Heating

6: 86 percent / conc. aq. NH₃ / CH₂Cl₂ / 48 h / Ambient temperature

7: Heating

8: 89 percent / CH₃ONa / dimethylformamide; methanol / 2 h

9: 65 percent / SO₂Cl₂ / acetic acid / 4 h / Ambient temperature

With hydrogenchloride; ammonium hydroxide; sulfuryl dichloride; sodium methylate; sodium; potassium carbonate; triethylamine; sodium iodide; In 1,4-dioxane; methanol; dichloromethane; acetic acid; N,N-dimethyl-formamide; acetone; benzene;
DOI:10.1002/ardp.19803130704

Reference yield:

: 40018-10-8
3-oxo-3-[2-(trifluoromethyl)phenyl]propanenitrile

: 40018-16-4
7-chloro-1-methyl-5-(2-trifluoromethyl-phenyl)-1,3-dihydro-thieno[2,3-e][1,4]diazepin-2-one

Guidance literature:: Multi-step reaction with 7 steps

1: 78 percent / Et₃N / dioxane / 0.5 h / Heating

2: K₂CO₃ / dioxane / 2 h / Ambient temperature

3: NaI / acetone / 1 h / Heating

4: 86 percent / conc. aq. NH₃ / CH₂Cl₂ / 48 h / Ambient temperature

5: Heating

6: 89 percent / CH₃ONa / dimethylformamide; methanol / 2 h

7: 65 percent / SO₂Cl₂ / acetic acid / 4 h / Ambient temperature

With ammonium hydroxide; sulfuryl dichloride; sodium methylate; potassium carbonate; triethylamine; sodium iodide; In 1,4-dioxane; methanol; dichloromethane; acetic acid; N,N-dimethyl-formamide; acetone;
DOI:10.1002/ardp.19803130704