4-[(2,3-Epoxypropoxy)methyl]-2,2-dimethyl-1,3-dioxolane

Base Information

• Chemical Name: 4-[(2,3-Epoxypropoxy)methyl]-2,2-dimethyl-1,3-dioxolane
• CAS No.: 1607-37-0
• Molecular Formula: C₉H₁₆O₄
• Molecular Weight: 188.224
• Hs Code.: 2932999099
• European Community (EC) Number: 605-224-8
• DSSTox Substance ID: DTXSID40448386
• Nikkaji Number: J1.885.114H
• Mol file: 1607-37-0.mol

Synonyms:1607-37-0;4-[(2,3-Epoxypropoxy)methyl]-2,2-dimethyl-1,3-dioxolane;2,2-dimethyl-4-(oxiran-2-ylmethoxymethyl)-1,3-dioxolane;2,2-dimethyl-4-((oxiran-2-ylmethoxy)methyl)-1,3-dioxolane;2,2-Dimethyl-4-{[(oxiran-2-yl)methoxy]methyl}-1,3-dioxolane;4-((2,3-epoxypropoxy)methyl)-2,2-dimethyl-1,3-dioxolane;2,2-dimethyl-4-[(oxiran-2-ylmethoxy)methyl]-1,3-dioxolane;SCHEMBL1700171;DTXSID40448386;Isopropylidenglycerolglycidyl ether;1,3-Dioxolane, 2,2-dimethyl-4-[(oxiranylmethoxy)methyl]-;BAA60737;AKOS006284576;AS-80471;FT-0690875;1-O,2-O-Isopropylidene-3-O-glycidylglycerol;C73040;2,3-(dimethylmethylenedioxy)propyl glycidyl ether;1,3-Dioxolane, 2,2-dimethyl-4-[(2-oxiranylmethoxy)methyl]-

Chemical Property of 4-[(2,3-Epoxypropoxy)methyl]-2,2-dimethyl-1,3-dioxolane

Chemical Property:

• Vapor Pressure: 0.014mmHg at 25°C
• Boiling Point: 266.474°C at 760 mmHg
• Flash Point: 113.528°C
• PSA: 40.22000
• Density: 1.085g/cm³
• LogP: 0.55330
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• XLogP3: 0
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 188.10485899
• Heavy Atom Count: 13
• Complexity: 181

Purity/Quality:

97% ^*data from raw suppliers

4-[(2,3-Epoxypropoxy)methyl]-2,2-dimethyl-1,3-dioxolane 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1(OCC(O1)COCC2CO2)C

Technology Process of 4-[(2,3-Epoxypropoxy)methyl]-2,2-dimethyl-1,3-dioxolane

There total 2 articles about 4-[(2,3-Epoxypropoxy)methyl]-2,2-dimethyl-1,3-dioxolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

epichlorohydrin (106-89-8,24969-06-0,13403-37-7) + (R,S)-2,2-dimethyl-1,3-dioxolane-4-methanol (100-79-8,36543-79-0) → 4-(oxiranylmethyloxymethyl)-2,2-dimethyl-1,3-dioxalane (1607-37-0)

Guidance literature:

With tetrabutylammomium bromide; sodium hydroxide; In toluene; at 10 - 20 ℃; for 48h;

DOI:10.1021/acs.biomac.0c01789

Reference yield:

→ 4-(oxiranylmethyloxymethyl)-2,2-dimethyl-1,3-dioxalane (1607-37-0)

Guidance literature:

Acetonglycerin 7, Epichlorhydrin;

Reference yield:

4-(oxiranylmethyloxymethyl)-2,2-dimethyl-1,3-dioxalane (1607-37-0) + propargyl alcohol (107-19-7) → prop-2-ynyloxymethyl-oxirane (18180-30-8)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 0 ℃;

DOI:10.1016/0040-4020(96)00278-5

upstream raw materials:

epichlorohydrin

(R,S)-2,2-dimethyl-1,3-dioxolane-4-methanol

Downstream raw materials:

prop-2-ynyloxymethyl-oxirane