(R)-2-(4-benzyl-2-methyl-piperazin-1-yl)-4-methoxymethyl-6-methylpyrimidine

Base Information

Chemical Name:(R)-2-(4-benzyl-2-methyl-piperazin-1-yl)-4-methoxymethyl-6-methylpyrimidine
CAS No.:400785-88-8
Molecular Formula:C₁₉H₂₆N₄O
Molecular Weight:326.442
Hs Code.:

Synonyms:(R)-2-(4-benzyl-2-methyl-piperazin-1-yl)-4-methoxymethyl-6-methylpyrimidine

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Chemical Property of (R)-2-(4-benzyl-2-methyl-piperazin-1-yl)-4-methoxymethyl-6-methylpyrimidine

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Technology Process of (R)-2-(4-benzyl-2-methyl-piperazin-1-yl)-4-methoxymethyl-6-methylpyrimidine

There total 2 articles about (R)-2-(4-benzyl-2-methyl-piperazin-1-yl)-4-methoxymethyl-6-methylpyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 6290-50-2
1-methoxypentane-2,4-dione

: (R)-4-benzyl-2-methyl-piperazine-1-carboxamidine bis(trifluoroacetate)

: 400785-88-8
(R)-2-(4-benzyl-2-methyl-piperazin-1-yl)-4-methoxymethyl-6-methylpyrimidine

Guidance literature:: (R)-4-benzyl-2-methyl-piperazine-1-carboxamidine bis(trifluoroacetate); With sodium isopropylate; In isopropyl alcohol; for 1h; Heating;

1-methoxypentane-2,4-dione; In isopropyl alcohol; for 19h; Further stages.; Heating;
DOI:10.1021/jm010440g

Reference yield:

: 400785-83-3
(R)-4-benzyl-2-methyl-piperazine-1-N,N'-bis(tert-butoxycarbonyl)carboxamidine

: 400785-88-8
(R)-2-(4-benzyl-2-methyl-piperazin-1-yl)-4-methoxymethyl-6-methylpyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: CH₂Cl₂ / 3 h / 20 °C

2.1: i-PrONa / propan-2-ol / 1 h / Heating

2.2: 70 percent / propan-2-ol / 19 h / Heating

With sodium isopropylate; In dichloromethane; isopropyl alcohol;
DOI:10.1021/jm010440g