C₂₂H₂₀FNO₅S

Base Information

• Chemical Name: C₂₂H₂₀FNO₅S
• CAS No.: 1374233-32-5
• Molecular Formula: C₂₂H₂₀FNO₅S
• Molecular Weight: 429.469
• Mol file: 1374233-32-5.mol

Synonyms:C₂₂H₂₀FNO₅S

Chemical Property of C₂₂H₂₀FNO₅S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₂H₂₀FNO₅S

There total 21 articles about C₂₂H₂₀FNO₅S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

diiodomethane (75-11-6) + C21H18FNO5S (1374233-37-0) → C22H20FNO5S (1374233-32-5)

Guidance literature:

diiodomethane; With diethylzinc; In 1,2-dichloro-ethane; toluene; at -78 - -15 ℃; Inert atmosphere;

C₂₁H₁₈FNO₅S; In 1,2-dichloro-ethane; toluene; at -78 - 20 ℃;

With water; lithium hydroxide; In tetrahydrofuran; methanol; at 70 ℃; for 2h; Product distribution / selectivity;

Reference yield:

C23H22FNO5S (1374233-31-4) → C22H20FNO5S (1374233-32-5)

Guidance literature:

C₂₃H₂₂FNO₅S; With lithium hydroxide; In tetrahydrofuran; methanol; at 70 ℃;

With hydrogenchloride; In tetrahydrofuran; methanol; water; at 0 ℃; Product distribution / selectivity;

Reference yield:

2-bromo-5-methoxyaniline (59557-92-5) → C22H20FNO5S (1374233-32-5)

Guidance literature:

Multi-step reaction with 12 steps

1.1: pyridine / dichloromethane / 0.5 h / 0 - 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 80 °C

3.1: triethylamine; lithium chloride / palladium diacetate; triphenylphosphine / N,N-dimethyl-formamide / 1.5 h / 120 °C / Inert atmosphere

4.1: diethylzinc / hexane; toluene / 0 - 20 °C

5.1: N-Bromosuccinimide / dichloromethane / 24 h / 0 - 20 °C

6.1: boron tribromide / dichloromethane / 0.33 h / 0 °C

6.2: Cooling with ice

7.1: triethylamine / dmap / tetrahydrofuran / 1.5 h / 0 - 20 °C

8.1: piperidine / bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tri-tert-butyl phosphine / N,N-dimethyl-formamide / 80 °C / Inert atmosphere

9.1: tetrabutyl ammonium fluoride / tetrahydrofuran / Inert atmosphere; Reflux

10.1: N-iodo-succinimide / chloroform; trifluoroacetic acid / 3 h / 20 °C

11.1: triethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 4 h / 60 °C

12.1: lithium hydroxide / tetrahydrofuran; methanol / 70 °C

12.2: 0 °C

With piperidine; pyridine; N-Bromosuccinimide; N-iodo-succinimide; tetrabutyl ammonium fluoride; diethylzinc; boron tribromide; potassium carbonate; triethylamine; lithium chloride; lithium hydroxide; dmap; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tri-tert-butyl phosphine; palladium diacetate; triphenylphosphine; In tetrahydrofuran; methanol; hexane; dichloromethane; chloroform; N,N-dimethyl-formamide; toluene; trifluoroacetic acid;

upstream raw materials:

diiodomethane

C₂₁H₁₈FNO₅S

2-bromo-5-methoxyaniline

4-bromo-3-nitroanizole

Downstream raw materials:

C₂₃H₂₃FN₂O₄S