C₁₀H₈FN₃O

Base Information

• Chemical Name: C₁₀H₈FN₃O
• CAS No.: 1047405-73-1
• Molecular Formula: C₁₀H₈FN₃O
• Molecular Weight: 205.191
• Mol file: 1047405-73-1.mol

Synonyms:C₁₀H₈FN₃O

Chemical Property of C₁₀H₈FN₃O

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₀H₈FN₃O

There total 1 articles about C₁₀H₈FN₃O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(5-fluoro-4-methoxypyrimidin-2-yl)phenylamine (1365748-94-2) → C10H8FN3O (1047405-73-1)

Guidance literature:

With hydrogenchloride; In water; at 100 ℃; for 12h;

DOI:10.1016/j.tetlet.2012.01.088

Reference yield:

C10H8FN3O (1047405-73-1) → C10H7ClFN3 (1047405-74-2)

Guidance literature:

With trichlorophosphate; at 100 ℃; for 12h;

DOI:10.1016/j.tetlet.2012.01.088

Reference yield:

C10H8FN3O (1047405-73-1) → C11H8FN3O2 (1365748-97-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: trichlorophosphate / 12 h / 100 °C

2.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine / 24 h / 50 °C / 2585.81 Torr

3.1: sodium hydroxide / methanol; water / 5 h / 20 °C

3.2: pH 6

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine; sodium hydroxide; trichlorophosphate; In methanol; water;

DOI:10.1016/j.tetlet.2012.01.088

upstream raw materials:

(5-fluoro-4-methoxypyrimidin-2-yl)phenylamine

Downstream raw materials:

C₁₀H₇ClFN₃

C₁₁H₈FN₃O₂

C₁₂H₁₁FN₄O