6-Chloro-2-methylquinolin-4-ol

Base Information

• Chemical Name: 6-Chloro-2-methylquinolin-4-ol
• CAS No.: 15644-86-7
• Molecular Formula: C10H8 Cl N O
• Molecular Weight: 193.633
• Hs Code.: 2933499090
• European Community (EC) Number: 653-105-4
• DSSTox Substance ID: DTXSID10935450
• Nikkaji Number: J1.402.574J,J1.634.625J
• Wikidata: Q72455213
• ChEMBL ID: CHEMBL1525792
• Mol file: 15644-86-7.mol

Synonyms:6-chloro-2-methylquinolin-4(1H)-one;HEI 713;HEI-713;HEI713

Chemical Property of 6-Chloro-2-methylquinolin-4-ol

Chemical Property:

• Vapor Pressure: 0.000483mmHg at 25°C
• Boiling Point: 313.9°Cat760mmHg
• Flash Point: 143.6°C
• PSA: 33.12000
• Density: 1.273g/cm³
• LogP: 2.90220
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 193.0294416
• Heavy Atom Count: 13
• Complexity: 262

Purity/Quality:

97% ^*data from raw suppliers

6-Chloro-2-methylquinolin-4-ol ^*data from reagent suppliers

Safty Information:

• Statements: 41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=O)C2=C(N1)C=CC(=C2)Cl

Technology Process of 6-Chloro-2-methylquinolin-4-ol

There total 9 articles about 6-Chloro-2-methylquinolin-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

C12H14ClNO2 (187386-90-9) → 6-chloro-2-methyl-quinolin-4-ol (15644-86-7)

Guidance literature:

In diphenylether; at 240 ℃; for 1h; Dean-Stark;

DOI:10.2174/1570180815666171212143339

Reference yield: 65.0%

ethyl acetoacetate (141-97-9) + 4-chloro-aniline (106-47-8) → 6-chloro-2-methyl-quinolin-4-ol (15644-86-7)

Guidance literature:

at 150 ℃; for 2h;

DOI:10.1016/j.ejmech.2020.112889

Reference yield: 13.0%

ethyl acetoacetate (141-97-9) + 4-chloro-aniline (106-47-8) → 6-chloro-2-methyl-quinolin-4-ol (15644-86-7)

Guidance literature:

ethyl acetoacetate; 4-chloro-aniline; at 130 ℃; for 1.5h;

In diphenylether; biphenyl; at 250 ℃; for 1h;

DOI:10.1021/acs.jmedchem.6b00245

upstream raw materials:

6-chloro-2-methyl-2,3-dihydro-1H-quinolin-4-one

ethyl 3-(4-chlorophenylamino)crotonate

ethyl acetoacetate

4-chloro-aniline

Downstream raw materials:

4,6-dichloro-2-methylquinoline

4-{[1-(4-Hydroxy-phenyl)-meth-(E)-ylidene]-amino}-benzoic acid 6-chloro-2-methyl-quinolin-4-yl ester

4-{[1-(4-Chloro-phenyl)-meth-(E)-ylidene]-amino}-benzoic acid 6-chloro-2-methyl-quinolin-4-yl ester

2-{[1-(4-Hydroxy-phenyl)-meth-(Z)-ylidene]-amino}-benzoic acid 6-chloro-2-methyl-quinolin-4-yl ester