6'-chloro-1-tosyl-4'-(2,2,2-trifluoroethyl)-3',4'-dihydrospiro[piperidine-4,2'-pyrimido[1,2-a]pyrimidin]-8'-(1'H)-one

Base Information

• Chemical Name: 6'-chloro-1-tosyl-4'-(2,2,2-trifluoroethyl)-3',4'-dihydrospiro[piperidine-4,2'-pyrimido[1,2-a]pyrimidin]-8'-(1'H)-one
• CAS No.: 1609547-86-5
• Molecular Formula: C₂₀H₂₂ClF₃N₄O₃S
• Molecular Weight: 490.934
• Mol file: 1609547-86-5.mol

Synonyms:6'-chloro-1-tosyl-4'-(2,2,2-trifluoroethyl)-3',4'-dihydrospiro[piperidine-4,2'-pyrimido[1,2-a]pyrimidin]-8'-(1'H)-one

Chemical Property of 6'-chloro-1-tosyl-4'-(2,2,2-trifluoroethyl)-3',4'-dihydrospiro[piperidine-4,2'-pyrimido[1,2-a]pyrimidin]-8'-(1'H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6'-chloro-1-tosyl-4'-(2,2,2-trifluoroethyl)-3',4'-dihydrospiro[piperidine-4,2'-pyrimido[1,2-a]pyrimidin]-8'-(1'H)-one

There total 4 articles about 6'-chloro-1-tosyl-4'-(2,2,2-trifluoroethyl)-3',4'-dihydrospiro[piperidine-4,2'-pyrimido[1,2-a]pyrimidin]-8'-(1'H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

S-(1-(4-((4,6-dichloropyrimidin-2-yl)amino)-1-tosylpiperidin-4-yl)-4,4,4-trifluorobutan-2-yl)-O-octadecyl carbonodithioate (1609547-85-4) → 6'-chloro-1-tosyl-4'-(2,2,2-trifluoroethyl)-3',4'-dihydrospiro[piperidine-4,2'-pyrimido[1,2-a]pyrimidin]-8'-(1'H)-one (1609547-86-5)

Guidance literature:

With 2,6-dimethylpyridine; dilauryl peroxide; In ethyl acetate; Inert atmosphere; Reflux;

DOI:10.1021/ol501104h

Reference yield:

N-(4-allyl-1-tosylpiperidin-4-yl)-4,6-dichloropyrimidin-2-amine (1609547-75-2) → 6'-chloro-1-tosyl-4'-(2,2,2-trifluoroethyl)-3',4'-dihydrospiro[piperidine-4,2'-pyrimido[1,2-a]pyrimidin]-8'-(1'H)-one (1609547-86-5)

Guidance literature:

Multi-step reaction with 2 steps

1: dilauryl peroxide / ethyl acetate / Inert atmosphere; Reflux

2: dilauryl peroxide; 2,6-dimethylpyridine / ethyl acetate / Inert atmosphere; Reflux

With 2,6-dimethylpyridine; dilauryl peroxide; In ethyl acetate;

DOI:10.1021/ol501104h

Reference yield:

4-allyl-1-tosylpiperidin-4-amine (1414889-98-7) → 6'-chloro-1-tosyl-4'-(2,2,2-trifluoroethyl)-3',4'-dihydrospiro[piperidine-4,2'-pyrimido[1,2-a]pyrimidin]-8'-(1'H)-one (1609547-86-5)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / tetrahydrofuran / 72 h / 90 °C / Inert atmosphere; Sealed tube

2: dilauryl peroxide / ethyl acetate / Inert atmosphere; Reflux

3: dilauryl peroxide; 2,6-dimethylpyridine / ethyl acetate / Inert atmosphere; Reflux

With 2,6-dimethylpyridine; dilauryl peroxide; triethylamine; In tetrahydrofuran; ethyl acetate;

DOI:10.1021/ol501104h

upstream raw materials:

S-(1-(4-((4,6-dichloropyrimidin-2-yl)amino)-1-tosylpiperidin-4-yl)-4,4,4-trifluorobutan-2-yl)-O-octadecyl carbonodithioate

N-(4-allyl-1-tosylpiperidin-4-yl)-4,6-dichloropyrimidin-2-amine

N-tosyl-4-piperidone

4-allyl-1-tosylpiperidin-4-amine