7α,10α-epoxy-2'-(triisopropylsilyloxy)-3'-dephenyl-3'-(2-furyl)-2-debenzoyl-2-(2,5-dimethoxybenzoyl)-docetaxel

Base Information

Chemical Name:7α,10α-epoxy-2'-(triisopropylsilyloxy)-3'-dephenyl-3'-(2-furyl)-2-debenzoyl-2-(2,5-dimethoxybenzoyl)-docetaxel
CAS No.:889470-87-5
Molecular Formula:C₅₂H₇₃NO₁₆Si
Molecular Weight:996.234
Hs Code.:

Synonyms:7α,10α-epoxy-2'-(triisopropylsilyloxy)-3'-dephenyl-3'-(2-furyl)-2-debenzoyl-2-(2,5-dimethoxybenzoyl)-docetaxel

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 7α,10α-epoxy-2'-(triisopropylsilyloxy)-3'-dephenyl-3'-(2-furyl)-2-debenzoyl-2-(2,5-dimethoxybenzoyl)-docetaxel

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Technology Process of 7α,10α-epoxy-2'-(triisopropylsilyloxy)-3'-dephenyl-3'-(2-furyl)-2-debenzoyl-2-(2,5-dimethoxybenzoyl)-docetaxel

There total 1 articles about 7α,10α-epoxy-2'-(triisopropylsilyloxy)-3'-dephenyl-3'-(2-furyl)-2-debenzoyl-2-(2,5-dimethoxybenzoyl)-docetaxel which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 889470-85-3
7-(trifluoromethanesulfonyloxy)-2'-(triisopropylsilyloxy)-3'-dephenyl-3'-(2-furyl)-10-oxo-2-debenzoyl-2-(2,5-dimethoxybenzoyl)-docetaxel

: 889470-87-5
7α,10α-epoxy-2'-(triisopropylsilyloxy)-3'-dephenyl-3'-(2-furyl)-2-debenzoyl-2-(2,5-dimethoxybenzoyl)-docetaxel

: 889470-86-4
7α,9α-epoxy-2'-(triisopropylsilyloxy)-3'-dephenyl-3'-(2-furyl)-2-debenzoyl-2-(2,5-dimethoxybenzoyl)-docetaxel

Guidance literature:: 7-(trifluoromethanesulfonyloxy)-2'-(triisopropylsilyloxy)-3'-dephenyl-3'-(2-furyl)-10-oxo-2-debenzoyl-2-(2,5-dimethoxybenzoyl)-docetaxel; With sodium tetrahydroborate; In ethanol; for 0.0833333h;

With water; In ethanol; ethyl acetate;