5-(5-{4-[5-(tert-butoxycarbonylaminomethyl)thiophen-2-yl]-7-methylthieno[3,2-d]pyrimidin-6-yl}-2-methoxypyridin-3-ylsulfamoyl)-2-chlorobenzoic acid

Base Information

Chemical Name:5-(5-{4-[5-(tert-butoxycarbonylaminomethyl)thiophen-2-yl]-7-methylthieno[3,2-d]pyrimidin-6-yl}-2-methoxypyridin-3-ylsulfamoyl)-2-chlorobenzoic acid
CAS No.:1414474-32-0
Molecular Formula:C₃₀H₂₈ClN₅O₇S₃
Molecular Weight:702.233
Hs Code.:

5-(5-{4-[5-(tert-butoxycarbonylaminomethyl)thiophen-2-yl]-7-methylthieno[3,2-d]pyrimidin-6-yl}-2-methoxypyridin-3-ylsulfamoyl)-2-chlorobenzoic acid

Synonyms:5-(5-{4-[5-(tert-butoxycarbonylaminomethyl)thiophen-2-yl]-7-methylthieno[3,2-d]pyrimidin-6-yl}-2-methoxypyridin-3-ylsulfamoyl)-2-chlorobenzoic acid

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Chemical Property of 5-(5-{4-[5-(tert-butoxycarbonylaminomethyl)thiophen-2-yl]-7-methylthieno[3,2-d]pyrimidin-6-yl}-2-methoxypyridin-3-ylsulfamoyl)-2-chlorobenzoic acid

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Technology Process of 5-(5-{4-[5-(tert-butoxycarbonylaminomethyl)thiophen-2-yl]-7-methylthieno[3,2-d]pyrimidin-6-yl}-2-methoxypyridin-3-ylsulfamoyl)-2-chlorobenzoic acid

There total 6 articles about 5-(5-{4-[5-(tert-butoxycarbonylaminomethyl)thiophen-2-yl]-7-methylthieno[3,2-d]pyrimidin-6-yl}-2-methoxypyridin-3-ylsulfamoyl)-2-chlorobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1414474-29-5
C₃₁H₃₀ClN₅O₇S₃

: 1414474-32-0
5-(5-{4-[5-(tert-butoxycarbonylaminomethyl)thiophen-2-yl]-7-methylthieno[3,2-d]pyrimidin-6-yl}-2-methoxypyridin-3-ylsulfamoyl)-2-chlorobenzoic acid

Guidance literature:: With lithium hydroxide monohydrate; In 1,4-dioxane; water; at 20 ℃; for 1h;
DOI:10.1021/acsmedchemlett.1c00412

Reference yield: 95.0%

: 1414474-32-0
5-(5-{4-[5-(tert-butoxycarbonylaminomethyl)thiophen-2-yl]-7-methylthieno[3,2-d]pyrimidin-6-yl}-2-methoxypyridin-3-ylsulfamoyl)-2-chlorobenzoic acid

Guidance literature:

Reference yield:

: 1414473-61-2
5-(4-chloro-7-methylthieno[3,2-d]pyrimidin-6-yl)-2-methoxy-pyridin-3-ylamine

: 1414474-32-0
5-(5-{4-[5-(tert-butoxycarbonylaminomethyl)thiophen-2-yl]-7-methylthieno[3,2-d]pyrimidin-6-yl}-2-methoxypyridin-3-ylsulfamoyl)-2-chlorobenzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / water; 1,2-dimethoxyethane / 24 h / Reflux; Inert atmosphere

2: pyridine / 3.5 h / 0 - 20 °C

3: lithium hydroxide monohydrate / water; 1,4-dioxane / 1 h / 20 °C

With pyridine; bis-triphenylphosphine-palladium(II) chloride; lithium hydroxide monohydrate; sodium carbonate; In 1,4-dioxane; 1,2-dimethoxyethane; water; 1: |Suzuki Coupling;
DOI:10.1021/acsmedchemlett.1c00412