(S)-2-amino-N-(1R,2R)-1-cyano-2-(4'-ethylbiphenyl-4-ylcyclopropyl)butanamide

Base Information

Chemical Name:(S)-2-amino-N-(1R,2R)-1-cyano-2-(4'-ethylbiphenyl-4-ylcyclopropyl)butanamide
CAS No.:1401624-48-3
Molecular Formula:C₂₂H₂₅N₃O
Molecular Weight:347.46
Hs Code.:

Synonyms:(S)-2-amino-N-(1R,2R)-1-cyano-2-(4'-ethylbiphenyl-4-ylcyclopropyl)butanamide

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Chemical Property of (S)-2-amino-N-(1R,2R)-1-cyano-2-(4'-ethylbiphenyl-4-ylcyclopropyl)butanamide

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Technology Process of (S)-2-amino-N-(1R,2R)-1-cyano-2-(4'-ethylbiphenyl-4-ylcyclopropyl)butanamide

There total 13 articles about (S)-2-amino-N-(1R,2R)-1-cyano-2-(4'-ethylbiphenyl-4-ylcyclopropyl)butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: 1401625-54-4
tert-butyl (S)-1-((1R,2R)-1-cyano-2-(4'-ethylbiphenyl-4-yl)cyclopropylamino)-1-oxobutan-2-ylcarbamate

: 1401624-48-3
(S)-2-amino-N-(1R,2R)-1-cyano-2-(4'-ethylbiphenyl-4-ylcyclopropyl)butanamide

Guidance literature:: tert-butyl (S)-1-((1R,2R)-1-cyano-2-(4'-ethylbiphenyl-4-yl)cyclopropylamino)-1-oxobutan-2-ylcarbamate; With formic acid; at 20 ℃; for 4h;

With sodium hydrogencarbonate; In water;

Reference yield:

: 1585-07-5
1-bromo-4-ethylbenzene

: 1401624-48-3
(S)-2-amino-N-(1R,2R)-1-cyano-2-(4'-ethylbiphenyl-4-ylcyclopropyl)butanamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / Inert atmosphere; Reflux

2: sodium carbonate / 1,4-dioxane / Inert atmosphere; Reflux

3: formic acid / 4 h / 20 °C

With formic acid; sodium carbonate; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; toluene;

Reference yield:

: methyl-1-amino-2-(4-bromophenyl)cyclopropane-1-carboxylate

: 1401624-48-3
(S)-2-amino-N-(1R,2R)-1-cyano-2-(4'-ethylbiphenyl-4-ylcyclopropyl)butanamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: DMT-MM / dichloromethane / 0 - 20 °C

2.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 3 h / 20 °C

2.2: pH 4

3.1: chloroformic acid ethyl ester; triethylamine / dichloromethane / 1 h / 0 °C

3.2: 20 °C

4.1: 1,3,5-trichloro-2,4,6-triazine / N,N-dimethyl-formamide / 4 h / 20 °C

5.1: sodium carbonate / 1,4-dioxane / Inert atmosphere; Reflux

6.1: formic acid / 4 h / 20 °C

With formic acid; 1,3,5-trichloro-2,4,6-triazine; lithium hydroxide monohydrate; DMT-MM; water; chloroformic acid ethyl ester; sodium carbonate; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;