N⁴-[2-(4-Chloro-benzyloxy)-6-methoxy-4-methyl-5-(3-trifluoromethyl-phenoxy)-quinolin-8-yl]-pentane-1,4-diamine

Base Information

• Chemical Name: N⁴-[2-(4-Chloro-benzyloxy)-6-methoxy-4-methyl-5-(3-trifluoromethyl-phenoxy)-quinolin-8-yl]-pentane-1,4-diamine
• CAS No.: 106635-92-1
• Molecular Formula: C₃₀H₃₁ClF₃N₃O₃
• Molecular Weight: 574.043

Synonyms:N⁴-[2-(4-Chloro-benzyloxy)-6-methoxy-4-methyl-5-(3-trifluoromethyl-phenoxy)-quinolin-8-yl]-pentane-1,4-diamine

Chemical Property of N⁴-[2-(4-Chloro-benzyloxy)-6-methoxy-4-methyl-5-(3-trifluoromethyl-phenoxy)-quinolin-8-yl]-pentane-1,4-diamine

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of N⁴-[2-(4-Chloro-benzyloxy)-6-methoxy-4-methyl-5-(3-trifluoromethyl-phenoxy)-quinolin-8-yl]-pentane-1,4-diamine

There total 8 articles about N⁴-[2-(4-Chloro-benzyloxy)-6-methoxy-4-methyl-5-(3-trifluoromethyl-phenoxy)-quinolin-8-yl]-pentane-1,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-{4-[2-(4-Chloro-benzyloxy)-6-methoxy-4-methyl-5-(3-trifluoromethyl-phenoxy)-quinolin-8-ylamino]-pentyl}-isoindole-1,3-dione (121963-34-6) → N4-[2-(4-Chloro-benzyloxy)-6-methoxy-4-methyl-5-(3-trifluoromethyl-phenoxy)-quinolin-8-yl]-pentane-1,4-diamine (106635-92-1)

Guidance literature:

With hydrazine hydrate; In ethanol; water; Heating;

DOI:10.1021/jm00128a010

Reference yield:

8-amino-6-methoxy-4-methyl-5-(3-trifluoromethylphenoxy)quinoline (82333-41-3) → N4-[2-(4-Chloro-benzyloxy)-6-methoxy-4-methyl-5-(3-trifluoromethyl-phenoxy)-quinolin-8-yl]-pentane-1,4-diamine (106635-92-1)

Guidance literature:

Multi-step reaction with 7 steps

1: 100 percent / xylene / 24 h / Heating

2: 63 percent / 100percent m-chloroperbenzoic acid / CHCl₃ / 41 h / Ambient temperature

3: 75 percent / POCl₃ / CHCl₃ / 2 h / Heating

4: 89 percent / N₂H₄*H₂O / ethanol; H₂O / 3 h / Heating

5: 67 percent / NaH / dimethylformamide; paraffin

6: 77 percent / diisopropylamine / acetonitrile / Heating

7: hydrazine hydrate / ethanol; H₂O / Heating

With sodium hydride; hydrazine hydrate; diisopropylamine; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate; In ethanol; chloroform; water; N,N-dimethyl-formamide; acetonitrile; paraffin; xylene;

DOI:10.1021/jm00128a010

Reference yield:

para-Chlorobenzyl alcohol (873-76-7) → N4-[2-(4-Chloro-benzyloxy)-6-methoxy-4-methyl-5-(3-trifluoromethyl-phenoxy)-quinolin-8-yl]-pentane-1,4-diamine (106635-92-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 67 percent / NaH / dimethylformamide; paraffin

2: 77 percent / diisopropylamine / acetonitrile / Heating

3: hydrazine hydrate / ethanol; H₂O / Heating

With sodium hydride; hydrazine hydrate; diisopropylamine; In ethanol; water; N,N-dimethyl-formamide; acetonitrile; paraffin;

DOI:10.1021/jm00128a010

upstream raw materials:

2-{4-[2-(4-Chloro-benzyloxy)-6-methoxy-4-methyl-5-(3-trifluoromethyl-phenoxy)-quinolin-8-ylamino]-pentyl}-isoindole-1,3-dione

8-amino-6-methoxy-4-methyl-5-(3-trifluoromethylphenoxy)quinoline

para-Chlorobenzyl alcohol

8-amino-2-chloro-6-methoxy-4-methyl-5-<3-(trifluoromethyl)phenoxy>quinoline

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