1-ETHYNYL-2-FLUOROBENZENE

Base Information

• Chemical Name: 1-ETHYNYL-2-FLUOROBENZENE
• CAS No.: 766-49-4
• Molecular Formula: C8H5 F
• Molecular Weight: 120.126
• Hs Code.: 2903999090
• Mol file: 766-49-4.mol

Synonyms:(o-Fluorophenyl)acetylene;1-Ethynyl-2-fluorobenzene; 2-Fluorophenylacetylene

Chemical Property of 1-ETHYNYL-2-FLUOROBENZENE

Chemical Property:

• Appearance/Colour: clear yellow to brownish liquid
• Vapor Pressure: 5.15mmHg at 25°C
• Refractive Index: 1.524-1.527
• Boiling Point: 150 °C
• Flash Point: 37 ºC
• PSA: 0.00000
• Density: 1.06
• LogP: 1.80700
• Storage Temp.: Refrigerator (+4°C)

Purity/Quality:

99% ^*data from raw suppliers

1-Ethynyl-2-fluorobenzene ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38-10
• Safety Statements: 37/39-26-16-36

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Employed in studies on the polymerization1 and cross-coupling2 of phenylacetylenes. 1-Ethynyl-2-fluorobenzene has been employed in the cross-coupling of phenylacetylenes. It may be used in the preparation of 3-(2-deoxy-β-D-ribofuranosyl)-6-(2-fluorophenyl)-2,3-dihydrofuro-[2,3-d]pyrimidin-2-one and 4-(2-fluorophenylethynyl)-3-methyl-5-phenylisoxazole.

Technology Process of 1-ETHYNYL-2-FLUOROBENZENE

There total 15 articles about 1-ETHYNYL-2-FLUOROBENZENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

o-(2,2-dichloro-1-fluoroethenyl)fluorobenzene → (2-fluorophenyl)acetylene (766-49-4)

Guidance literature:

With n-butyllithium; In diethyl ether;

DOI:10.1246/bcsj.61.1625

Reference yield: 79.0%

4-(2-fluoro-phenyl)-2-methyl-but-3-yn-2-ol (178173-84-7) → (2-fluorophenyl)acetylene (766-49-4)

Guidance literature:

With potassium hydroxide; In paraffin; for 0.5h; under 1 Torr; Heating;

DOI:10.1055/s-1996-4265

Reference yield: 72.0%

(Z)-1-[2-bromovinyl]-2-fluorobenzene (187463-12-3) → (2-fluorophenyl)acetylene (766-49-4)

Guidance literature:

With potassium hydroxide; In ethanol; at 25 ℃;

upstream raw materials:

4-(2-fluoro-phenyl)-2-methyl-but-3-yn-2-ol

(Z)-1-[2-bromovinyl]-2-fluorobenzene

2-fluorocinnamic acid

2,3-Dibromo-3-(2-fluorophenyl)propionic acid

Refernces

• 1、 Thiel, Niklas O.,Kemper, Sebastian,Teichert, Johannes F.. "Copper(I)-catalyzed stereoselective hydrogenation of 1,3-diynes and enynes". . p. 5023 - 5028. Retrieved 2017/07/27.
• 2、 Desai, Bimbisar,Dixon, Karen,Farrant, Elizabeth,Feng, Qixing,Gibson, Karl R.,Van Hoorn, Willem P.,Mills, James,Morgan, Trevor,Parry, David M.,Ramjee, Manoj K.,Selway, Christopher N.,Tarver, Gary J.,Whitlock, Gavin,Wright, Adrian G.. "Rapid discovery of a novel series of Abl kinase inhibitors by application of an integrated microfluidic synthesis and screening platform". supporting information. p. 3033 - 3047. Retrieved 2013/05/22.