4-methyl-3-[[4-(2,5-dimethyl-3-furanyl)-2-pyrimidinyl]amino]benzoic acid

Base Information

• Chemical Name: 4-methyl-3-[[4-(2,5-dimethyl-3-furanyl)-2-pyrimidinyl]amino]benzoic acid
• CAS No.: 1186620-36-9
• Molecular Formula: C₁₈H₁₇N₃O₃
• Molecular Weight: 323.351
• Mol file: 1186620-36-9.mol

Synonyms:4-methyl-3-[[4-(2,5-dimethyl-3-furanyl)-2-pyrimidinyl]amino]benzoic acid

Chemical Property of 4-methyl-3-[[4-(2,5-dimethyl-3-furanyl)-2-pyrimidinyl]amino]benzoic acid

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 4-methyl-3-[[4-(2,5-dimethyl-3-furanyl)-2-pyrimidinyl]amino]benzoic acid

There total 2 articles about 4-methyl-3-[[4-(2,5-dimethyl-3-furanyl)-2-pyrimidinyl]amino]benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-methyl-3-[[4-(2,5-dimethyl-3-furanyl)-2-pyrimidinyl]amino]benzoic acid methyl ester (1186620-35-8) → 4-methyl-3-[[4-(2,5-dimethyl-3-furanyl)-2-pyrimidinyl]amino]benzoic acid (1186620-36-9)

Guidance literature:

4-methyl-3-[[4-(2,5-dimethyl-3-furanyl)-2-pyrimidinyl]amino]benzoic acid methyl ester; With water; sodium hydroxide; In tetrahydrofuran; methanol; at 60 ℃; for 6h;

With citric acid; In water; pH=4 - 4.5;

Reference yield:

3-guanidino-4-methylbenzoic acid methyl ester (1025716-98-6) + 3-dimethylamino-1-(2,5-dimethylfuran-3-yl)-propenone (112677-14-2) → 4-methyl-3-[[4-(2,5-dimethyl-3-furanyl)-2-pyrimidinyl]amino]benzoic acid (1186620-36-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydroxide / isopropyl alcohol / 68 h / Reflux

2.1: water; sodium hydroxide / tetrahydrofuran; methanol / 6 h / 60 °C

2.2: pH 4 - 4.5

With water; sodium hydroxide; In tetrahydrofuran; methanol; isopropyl alcohol;

upstream raw materials:

4-methyl-3-[[4-(2,5-dimethyl-3-furanyl)-2-pyrimidinyl]amino]benzoic acid methyl ester

3-guanidino-4-methylbenzoic acid methyl ester

3-dimethylamino-1-(2,5-dimethylfuran-3-yl)-propenone