(Boc-aminooxy)acetic acid

Base Information Edit

Chemical Name:(Boc-aminooxy)acetic acid
CAS No.:42989-85-5
Molecular Formula:C7H13NO5
Molecular Weight:191.184
Hs Code.:2928 00 90
European Community (EC) Number:628-980-0
DSSTox Substance ID:DTXSID10373171
Nikkaji Number:J1.289.261F
Wikidata:Q72448316
Mol file:42989-85-5.mol

Synonyms:(Boc-aminooxy)acetic acid;42989-85-5;Boc-Aoa-OH;2-(((tert-Butoxycarbonyl)amino)oxy)acetic acid;Boc-AOAc-OH;2-[(2-methylpropan-2-yl)oxycarbonylamino]oxyacetic Acid;N-Boc-(carboxymethoxy)amine;2-({[(tert-butoxy)carbonyl]amino}oxy)acetic acid;Boc-3-(aminooxy)acetic acid;MFCD01632027;Acetic acid, [[[(1,1-dimethylethoxy)carbonyl]amino]oxy]-;2-(tert-butoxycarbonylaminooxy)acetic acid;Boc-aminooxyacetic acid;2-(Boc-aminooxy)-acetic acid;N-Boc-(carboxymethoxy)-amine;Boc-(nhoac)-oh;(Boc)aminooxyacetic acid;[(tert-Butoxycarbonyl)aminooxy]acetic Acid;(Boc-aminoxy)acetic acid;2-(t-Butyloxycarbonyl-aminooxy)-acetic acid;t-Boc-aminooxyacetic Acid;SCHEMBL307685;DTXSID10373171;QBXODCKYUZNZCY-UHFFFAOYSA-N;tert-Butoxycarbonylaminooxyacetic acid;Boc-AOA Tert-Boc-aminooxyacetic acid;AKOS009156496;GS-6570;tert-butyloxycarbonylaminoxy acetic acid;N-tert-butoxycarbonyl aminooxyacetic acid;SY019091;(Boc-aminooxy)acetic acid, >=98.0% (T);2-(tert-Butyloxycarbonylaminooxy)acetic acid;2-[(tert-Butoxycarbonylamino)oxy]acetic acid;B3338;CS-0030574;FT-0662558;EN300-227480;H10114;[(1,1-Dimethylethoxy)carbonyl]aminooxyacetic acid;A850863;[(1,1-dimethylethoxy)carbonyl]aminooxy acetic acid;J-501795;J-650267

Suppliers and Price of (Boc-aminooxy)acetic acid

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
t-Boc-aminooxyacetic acid
50mg
$ 446.00

TRC
t-Boc-aminooxyaceticAcid
25g
$ 910.00

TCI Chemical
[(tert-Butoxycarbonyl)aminooxy]acetic Acid >98.0%(T)
1g
$ 18.00

TCI Chemical
[(tert-Butoxycarbonyl)aminooxy]acetic Acid >98.0%(T)
5g
$ 53.00

Sigma-Aldrich
Boc-amino-oxyacetic acid Novabiochem?
5 g
$ 242.00

Sigma-Aldrich
(Boc-aminooxy)acetic acid ≥98.0% (T)
5g
$ 426.00

Sigma-Aldrich
Boc-amino-oxyacetic acid Novabiochem . CAS 42989-85-5, molar mass 191.18 g/mol., Novabiochem
8510170005
$ 234.00

Sigma-Aldrich
(Boc-aminooxy)acetic acid ≥98.0% (T)
1g
$ 124.00

Sigma-Aldrich
Boc-amino-oxyacetic acid Novabiochem?
1 g
$ 59.80

Sigma-Aldrich
Boc-amino-oxyacetic acid Novabiochem . CAS 42989-85-5, molar mass 191.18 g/mol., Novabiochem
8510170001
$ 57.80

Total 85 raw suppliers

Chemical Property of (Boc-aminooxy)acetic acid Edit

Chemical Property:

Melting Point:~115 °C (dec.)
Refractive Index:1.46
PKA:2.97±0.10(Predicted)
PSA：84.86000
Density:1.214 g/cm³
LogP:0.91820
Storage Temp.:2-8°C
Solubility.:Soluble in methanol.
XLogP3:0.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:191.07937252
Heavy Atom Count:13
Complexity:196

Purity/Quality:

97% ^*data from raw suppliers

t-Boc-aminooxyacetic acid ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-36

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)NOCC(=O)O
General Description (BOC-AMINOOXY)ACETIC ACID is a chemical compound used in chemoselective ligation strategies, particularly for oxime bond formation in peptide and protein conjugation. It serves as a protected aminooxyacetic acid derivative, where the tert-butoxycarbonyl (BOC) group shields the aminooxy functionality, enabling controlled reactions with aldehyde-containing molecules. This reagent facilitates site-specific modifications, such as in the synthesis of template-assembled synthetic proteins (TASP) or antibody conjugates, where its stable oxime linkage improves in vivo stability and targeting efficiency. The BOC group can be deprotected to expose the reactive aminooxy group, allowing conjugation under mild aqueous conditions, making it valuable in bioconjugation and drug development applications. **Returned paragraph (conclusion):** (BOC-AMINOOXY)ACETIC ACID is a versatile reagent for chemoselective oxime ligation, enabling stable conjugations in peptide synthesis, antibody labeling, and bioconjugation. Its BOC-protected aminooxy group ensures controlled reactivity, facilitating site-specific modifications with aldehyde-functionalized molecules, which is critical for applications in targeted drug delivery and protein engineering.

Technology Process of (Boc-aminooxy)acetic acid

There total 7 articles about (Boc-aminooxy)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%