2-((1R,2R)-2-Amino-1-ethyl-3-methoxymethoxy-1-methyl-propoxy)-4-bromo-benzonitrile

Base Information

Chemical Name:2-((1R,2R)-2-Amino-1-ethyl-3-methoxymethoxy-1-methyl-propoxy)-4-bromo-benzonitrile
CAS No.:401606-73-3
Molecular Formula:C₁₅H₂₁BrN₂O₃
Molecular Weight:357.247
Hs Code.:

Synonyms:2-((1R,2R)-2-Amino-1-ethyl-3-methoxymethoxy-1-methyl-propoxy)-4-bromo-benzonitrile

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Chemical Property of 2-((1R,2R)-2-Amino-1-ethyl-3-methoxymethoxy-1-methyl-propoxy)-4-bromo-benzonitrile

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Technology Process of 2-((1R,2R)-2-Amino-1-ethyl-3-methoxymethoxy-1-methyl-propoxy)-4-bromo-benzonitrile

There total 4 articles about 2-((1R,2R)-2-Amino-1-ethyl-3-methoxymethoxy-1-methyl-propoxy)-4-bromo-benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.2%

: 105942-08-3
4-bromo-6-fluorobenzonitrile

: 401606-56-2
(2R,3R)-2-Amino-1-methoxymethoxy-3-methyl-pentan-3-ol

: 401606-73-3
2-((1R,2R)-2-Amino-1-ethyl-3-methoxymethoxy-1-methyl-propoxy)-4-bromo-benzonitrile

Guidance literature:: With potassium hexamethylsilazane; In tetrahydrofuran; toluene; at 0 ℃; for 2h;
DOI:10.1021/ja017277z

Reference yield:

: 167102-72-9
(2R,3R) 2-<(tert-butoxycarbonyl)amino>-3-methyl-1,3-pentanediol

: 401606-73-3
2-((1R,2R)-2-Amino-1-ethyl-3-methoxymethoxy-1-methyl-propoxy)-4-bromo-benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 3.09 g / iPr₂NEt / CH₂Cl₂ / 14 h / 25 °C

2: 78 percent / TFA / CH₂Cl₂ / 0.83 h / 0 °C

3: 78.2 percent / KHMDS / tetrahydrofuran; toluene / 2 h / 0 °C

With potassium hexamethylsilazane; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/ja017277z

Reference yield:

: 167102-68-3
(R)-4-((R)-1-hydroxy-1-methylpropyl)-2,2-dimethyl oxazolidine-3-carboxylic acid tert-butyl ester

: 401606-73-3
2-((1R,2R)-2-Amino-1-ethyl-3-methoxymethoxy-1-methyl-propoxy)-4-bromo-benzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: p-TsOH / methanol / 0.5 h / 20 °C

2: 3.09 g / iPr₂NEt / CH₂Cl₂ / 14 h / 25 °C

3: 78 percent / TFA / CH₂Cl₂ / 0.83 h / 0 °C

4: 78.2 percent / KHMDS / tetrahydrofuran; toluene / 2 h / 0 °C

With potassium hexamethylsilazane; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; toluene;
DOI:10.1021/ja017277z