C₃₉H₆₇NO₇SSi₂

Base Information

• Chemical Name: C₃₉H₆₇NO₇SSi₂
• CAS No.: 85453-63-0
• Molecular Formula: C₃₉H₆₇NO₇SSi₂
• Molecular Weight: 750.2
• Mol file: 85453-63-0.mol

Synonyms:C₃₉H₆₇NO₇SSi₂

Chemical Property of C₃₉H₆₇NO₇SSi₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₉H₆₇NO₇SSi₂

There total 4 articles about C₃₉H₆₇NO₇SSi₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

(5Z,13E,8R,9S,11R,12S,15S)-11,15-Bis(tert-butyldimethylsiloxy)-9-(methylamino)-8-(phenylsulfonyl)-5,13-prostadienoic acid (77494-48-5) → C39H67NO7SSi2 (85453-63-0) + (5Z,13E,8R,11R,12S,15S)-11,15-Bis(tert-butyldimethylsiloxy)-9-(anti-oximino)-8-(phenylsulfonyl)-5,13-prostadienoic acid (85548-84-1)

Guidance literature:

With peracetic acid; sodium tungstate; sodium carbonate; In methanol; water; at 25 ℃; for 10h;

DOI:10.1021/jo00161a010

Reference yield:

Methyl (5Z,13E,8R,9S,11R,12S,15S)-11,15-Bis(tert-butyldimethylsiloxy)-9-(dimethylamino)-8-(phenylsulfonyl)-5,13-prostadienoate (77506-98-0) → C39H67NO7SSi2 (85453-63-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 96 percent / sodium bicarbonate / CH₂Cl₂ / 72 h / 30 °C

2: 92 percent / zinc powder / tetrahydrofuran / 3 h / Heating

3: 101 percent / sodium hydroxide / methanol / 48 h

4: 5 percent / CH₃CO₃H, Na₂CO₃, Na₂WO₄ / methanol; H₂O

With peracetic acid; sodium hydroxide; sodium tungstate; sodium hydrogencarbonate; sodium carbonate; zinc; In tetrahydrofuran; methanol; dichloromethane; water;

DOI:10.1021/jo00161a010

Reference yield:

Methyl (5Z,13E,8R,9S,11R,12S,15S)-11,15-Bis(tert-butyldimethylsiloxy)-9-(methylamino)-8-(phenylsulfonyl)-5,13-prostadienoate (77494-47-4) → C39H67NO7SSi2 (85453-63-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 101 percent / sodium hydroxide / methanol / 48 h

2: 5 percent / CH₃CO₃H, Na₂CO₃, Na₂WO₄ / methanol; H₂O

With peracetic acid; sodium hydroxide; sodium tungstate; sodium carbonate; In methanol; water;

DOI:10.1021/jo00161a010

upstream raw materials:

(5Z,13E,8R,9S,11R,12S,15S)-11,15-Bis(tert-butyldimethylsiloxy)-9-(methylamino)-8-(phenylsulfonyl)-5,13-prostadienoic acid

Methyl (5Z,13E,8R,9S,11R,12S,15S)-11,15-Bis(tert-butyldimethylsiloxy)-9-(methylamino)-8-(phenylsulfonyl)-5,13-prostadienoate

Methyl (5Z,13E,8R,9S,11R,12S,15S)-11,15-Bis(tert-butyldimethylsiloxy)-9-(dimethylamino)-8-(phenylsulfonyl)-5,13-prostadienoate

Methyl (5Z,13E,8R,9S,11R,12S,15S)-11,15-Bis(tert-butyldimethylsiloxy)-9-<methylamino>-8-(phenylsulfonyl)-5,13-prostadienoate