4-((E)-2-dimethylamine-vinyl)-2-fluoro-5-nitrobenzoic acid methyl ester

Base Information

Chemical Name:4-((E)-2-dimethylamine-vinyl)-2-fluoro-5-nitrobenzoic acid methyl ester
CAS No.:1609967-04-5
Molecular Formula:C₁₂H₁₃FN₂O₄
Molecular Weight:268.245
Hs Code.:

Synonyms:4-((E)-2-dimethylamine-vinyl)-2-fluoro-5-nitrobenzoic acid methyl ester

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Chemical Property of 4-((E)-2-dimethylamine-vinyl)-2-fluoro-5-nitrobenzoic acid methyl ester

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Technology Process of 4-((E)-2-dimethylamine-vinyl)-2-fluoro-5-nitrobenzoic acid methyl ester

There total 3 articles about 4-((E)-2-dimethylamine-vinyl)-2-fluoro-5-nitrobenzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 753924-48-0
2-fluoro-4-methyl-5-nitrobenzoic acid methyl ester

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 1609967-04-5
4-((E)-2-dimethylamine-vinyl)-2-fluoro-5-nitrobenzoic acid methyl ester

Guidance literature:: In N,N-dimethyl-formamide; at 100 ℃; for 2h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.8b01550

Reference yield:

: 753924-40-2
2-fluoro-4-methyl-5-nitrobenzoic acid

: 1609967-04-5
4-((E)-2-dimethylamine-vinyl)-2-fluoro-5-nitrobenzoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran; diethyl ether / 0.5 h / 0 °C

2: N,N-dimethyl-formamide / 1 h / 100 °C

In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide;

Reference yield:

: 7697-23-6
2-fluoro-4-methylbenzoic Acid

: 1609967-04-5
4-((E)-2-dimethylamine-vinyl)-2-fluoro-5-nitrobenzoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: sulfuric acid; nitric acid / 1 h / 0 °C

2: tetrahydrofuran; diethyl ether / 0.5 h / 0 °C

3: N,N-dimethyl-formamide / 1 h / 100 °C

With sulfuric acid; nitric acid; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide;