1-Boc-3-Benzylpiperazine

Base Information

• Chemical Name: 1-Boc-3-Benzylpiperazine
• CAS No.: 502649-29-8
• Molecular Formula: C16H24 N2 O2
• Molecular Weight: 276.379
• Hs Code.: 2933599090
• Mol file: 502649-29-8.mol

Synonyms:3-Benzylpiperazine-1-carboxylicacid tert-butyl ester; tert-Butyl 3-benzylpiperazine-1-carboxylate

Chemical Property of 1-Boc-3-Benzylpiperazine

Chemical Property:

• Vapor Pressure: 5.7E-06mmHg at 25°C
• Boiling Point: 379.8oC at 760 mmHg
• PKA: 8.45±0.40(Predicted)
• Flash Point: 183.5oC
• PSA: 41.57000
• Density: 1.066g/cm3
• LogP: 2.70470
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99.3% ^*data from raw suppliers

1-Boc-3-benzylpiperazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 1-Boc-3-benzylpiperazine is a useful reactant/reagent for organic reactions and synthesis.

Technology Process of 1-Boc-3-Benzylpiperazine

There total 7 articles about 1-Boc-3-Benzylpiperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

tert-butyl 3-oxo-1-phenyltetrahydro-1H-oxazolo[3,4-a]pyrazine-7(3H)-carboxylate (847554-73-8) → 3-benzyl-piperazine-1-carboxylic acid tert-butyl ester (502649-29-8)

Guidance literature:

With palladium dihydroxide; ammonium formate; In ethanol; at 70 ℃; for 2h;

DOI:10.1016/j.tet.2007.01.044

Reference yield:

L-phenylalanine (63-91-2,25191-15-5,658-69-5,67675-33-6) → 3-benzyl-piperazine-1-carboxylic acid tert-butyl ester (502649-29-8)

Guidance literature:

Reference yield:

2-(hydroxy-phenyl-methyl)-piperazine-1,4-dicarboxylic acid di-tert-butyl ester → 3-benzyl-piperazine-1-carboxylic acid tert-butyl ester (502649-29-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 0.147 g / NaH / tetrahydrofuran; various solvent(s) / 1 h / Heating

2: 88 percent / Pd(OH)2/C; ammonium formate / ethanol / 2 h / 70 °C

With palladium dihydroxide; ammonium formate; sodium hydride; In tetrahydrofuran; ethanol;

DOI:10.1016/j.tet.2007.01.044

upstream raw materials:

tert-butyl 3-oxo-1-phenyltetrahydro-1H-oxazolo[3,4-a]pyrazine-7(3H)-carboxylate

di-tert-butyl dicarbonate

2-formylpiperazine-1,4-dicarboxylic acid di-tert-butyl ester

2-hydroxymethylpiperazine-1,4-dicarboxylic acid di-tert-butyl ester

Downstream raw materials:

C₃₅H₃₉N₃O₃

C₂₉H₃₅N₃O₃

tert-butyl 3-benzyl-4-(4-(4-(trifluoromethoxy)phenyl)-1H-1,2,3-triazole-1-carbonyl)piperazine-1-carboxylate

benzyl-2-benzylpiperazine-1-carboxylate

Refernces

• 1、 -. "PIPERAZINE AND HOMOPIPERAZINE COMPOUNDS". . . Retrieved 2008/06/13.