(1-(phenylsulfonyl)-2-(4-(trifluoromethyl)phenyl)-1H-imidazol-4-yl)(3,4,5-trimethoxyphenyl)methanone

Base Information

• Chemical Name: (1-(phenylsulfonyl)-2-(4-(trifluoromethyl)phenyl)-1H-imidazol-4-yl)(3,4,5-trimethoxyphenyl)methanone
• CAS No.: 1253697-83-4
• Molecular Formula: C₂₆H₂₁F₃N₂O₆S
• Molecular Weight: 546.524
• Mol file: 1253697-83-4.mol

Synonyms:(1-(phenylsulfonyl)-2-(4-(trifluoromethyl)phenyl)-1H-imidazol-4-yl)(3,4,5-trimethoxyphenyl)methanone

Chemical Property of (1-(phenylsulfonyl)-2-(4-(trifluoromethyl)phenyl)-1H-imidazol-4-yl)(3,4,5-trimethoxyphenyl)methanone

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of (1-(phenylsulfonyl)-2-(4-(trifluoromethyl)phenyl)-1H-imidazol-4-yl)(3,4,5-trimethoxyphenyl)methanone

There total 1 articles about (1-(phenylsulfonyl)-2-(4-(trifluoromethyl)phenyl)-1H-imidazol-4-yl)(3,4,5-trimethoxyphenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.7%

1-(phenylsulfonyl)-2-(4-(trifluoromethyl)phenyl)-1H-imidazole (1253697-59-4) + 3,4,5-Trimethoxybenzoyl chloride (4521-61-3) → (1-(phenylsulfonyl)-2-(4-(trifluoromethyl)phenyl)-1H-imidazol-4-yl)(3,4,5-trimethoxyphenyl)methanone (1253697-83-4)

Guidance literature:

1-(phenylsulfonyl)-2-(4-(trifluoromethyl)phenyl)-1H-imidazole; With tert.-butyl lithium; In tetrahydrofuran; pentane; at -78 ℃; for 0.166667h; Inert atmosphere;

3,4,5-Trimethoxybenzoyl chloride; In tetrahydrofuran; pentane; at -78 ℃; Inert atmosphere;

DOI:10.1021/jm100884b

Reference yield: 85.3%

(1-(phenylsulfonyl)-2-(4-(trifluoromethyl)phenyl)-1H-imidazol-4-yl)(3,4,5-trimethoxyphenyl)methanone (1253697-83-4) → (2-(4-(trifluoromethyl)phenyl)-1H-imidazol-4-yl)(3,4,5-trimethoxyphenyl)methanone (1253698-07-5)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃;

DOI:10.1021/jm100884b

upstream raw materials:

1-(phenylsulfonyl)-2-(4-(trifluoromethyl)phenyl)-1H-imidazole

3,4,5-Trimethoxybenzoyl chloride

Downstream raw materials:

(2-(4-(trifluoromethyl)phenyl)-1H-imidazol-4-yl)(3,4,5-trimethoxyphenyl)methanone