C₄₁H₄₇N₆O₁₄P

Base Information

• Chemical Name: C₄₁H₄₇N₆O₁₄P
• CAS No.: 1608113-36-5
• Molecular Formula: C₄₁H₄₇N₆O₁₄P
• Molecular Weight: 878.83
• Mol file: 1608113-36-5.mol

Synonyms:C₄₁H₄₇N₆O₁₄P

Chemical Property of C₄₁H₄₇N₆O₁₄P

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₁H₄₇N₆O₁₄P

There total 14 articles about C₄₁H₄₇N₆O₁₄P which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

N-For-Gly-L-β-amino-Ala-L-Phe-OMe (1608114-12-0) + C31H30N3O12P (1608113-35-4) → C41H47N6O14P (1608113-36-5)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 16h; Inert atmosphere;

DOI:10.1002/ejoc.201301781

Reference yield:

Dibenzyl N,N-diisopropylphosphoramidite (108549-23-1) → C41H47N6O14P (1608113-36-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 1H-tetrazole / dichloromethane; acetonitrile / 12 h / 0 - 20 °C / Inert atmosphere

1.2: 2 h / -40 - 20 °C / Inert atmosphere

2.1: ammonia / methanol / 27 h / 0 - 20 °C / Inert atmosphere

3.1: pyridine / dichloromethane / 26 h / 0 - 20 °C / Inert atmosphere

4.1: triethylamine / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

With pyridine; 1H-tetrazole; ammonia; triethylamine; In methanol; dichloromethane; acetonitrile;

DOI:10.1002/ejoc.201301781

Reference yield:

thymidine (50-89-5,28854-96-8,3545-96-8,50-88-4) → C41H47N6O14P (1608113-36-5)

Guidance literature:

Multi-step reaction with 6 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

2.1: trifluoroacetic acid / water; dichloromethane / 4 h / 0 °C

3.1: 1H-tetrazole / dichloromethane; acetonitrile / 12 h / 0 - 20 °C / Inert atmosphere

3.2: 2 h / -40 - 20 °C / Inert atmosphere

4.1: triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere

5.1: pyridine / dichloromethane / 26 h / 0 - 20 °C / Inert atmosphere

6.1: triethylamine / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

With pyridine; 1H-imidazole; 1H-tetrazole; triethylamine tris(hydrogen fluoride); triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1002/ejoc.201301781

upstream raw materials:

thymidine

Dibenzyl N,N-diisopropylphosphoramidite

N-For-Gly-L-β-amino-Ala(Fmoc)-L-Phe-OMe

N-For-Gly-L-β-amino-Ala-L-Phe-OMe