2,5-bisbenzyloxybenzyl cyanide

Base Information

• Chemical Name: 2,5-bisbenzyloxybenzyl cyanide
• CAS No.: 78283-40-6
• Molecular Formula: C₂₂H₁₉NO₂
• Molecular Weight: 329.398
• Mol file: 78283-40-6.mol

Synonyms:2,5-bisbenzyloxybenzyl cyanide

Chemical Property of 2,5-bisbenzyloxybenzyl cyanide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,5-bisbenzyloxybenzyl cyanide

There total 7 articles about 2,5-bisbenzyloxybenzyl cyanide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.4%

sodium cyanide (143-33-9,25596-52-5) + 2,5-bisbenzyloxybenzyl chloride (78283-39-3) → 2,5-bisbenzyloxybenzyl cyanide (78283-40-6)

Guidance literature:

In dimethyl sulfoxide; for 3h; Ambient temperature;

DOI:10.1248/cpb.29.744

Reference yield: 65.0%

potassium cyanide (151-50-8) + 2,5-bisbenzyloxybenzyl chloride (78283-39-3) → 2,5-bisbenzyloxybenzyl cyanide (78283-40-6)

Guidance literature:

Heating;

DOI:10.1039/P19810002570

Reference yield:

2,5-dihydroxybenzoic acid. (490-79-9) → 2,5-bisbenzyloxybenzyl cyanide (78283-40-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 93 percent / K₂CO₃ / dimethylformamide / 20 h / 100 °C

2: 65.6 percent / LiAlH₄ / tetrahydrofuran / 1.5 h / Ambient temperature

3: 88.8 percent / SOCl₂ / benzene; CH₂Cl₂; pyridine / below 10 deg C, then 4 deg C, 1 h

4: 90.4 percent / dimethylsulfoxide / 3 h / Ambient temperature

With lithium aluminium tetrahydride; thionyl chloride; potassium carbonate; In tetrahydrofuran; pyridine; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; benzene;

DOI:10.1248/cpb.29.744

upstream raw materials:

sodium cyanide

2,5-bisbenzyloxybenzyl chloride

potassium cyanide

2,5-dihydroxybenzoic acid.

Downstream raw materials:

N-(2,5-dibenzyloxyphenethyl)-2-(3,4,5-trimethoxyphenyl)acetamide

5,8-dihydroxy-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride

5,8-dibenzyloxy-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline

1-(2,5-dihydroxyphenyl)propan-2-one