(2S,3R,6R)-3-benzyloxy-1-(methoxycarbonyl)-2-(methoxymethoxy)methyl-6-(trityloxy)-methylpiperidine

Base Information

Chemical Name:(2S,3R,6R)-3-benzyloxy-1-(methoxycarbonyl)-2-(methoxymethoxy)methyl-6-(trityloxy)-methylpiperidine
CAS No.:153198-46-0
Molecular Formula:C₃₇H₄₁NO₆
Molecular Weight:595.736
Hs Code.:

Synonyms:(2S,3R,6R)-3-benzyloxy-1-(methoxycarbonyl)-2-(methoxymethoxy)methyl-6-(trityloxy)-methylpiperidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,3R,6R)-3-benzyloxy-1-(methoxycarbonyl)-2-(methoxymethoxy)methyl-6-(trityloxy)-methylpiperidine

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Technology Process of (2S,3R,6R)-3-benzyloxy-1-(methoxycarbonyl)-2-(methoxymethoxy)methyl-6-(trityloxy)-methylpiperidine

There total 2 articles about (2S,3R,6R)-3-benzyloxy-1-(methoxycarbonyl)-2-(methoxymethoxy)methyl-6-(trityloxy)-methylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 107-30-2
chloromethyl methyl ether

: (3R,6R)-3-Benzyloxy-2-hydroxymethyl-6-trityloxymethyl-piperidine-1-carboxylic acid methyl ester

: (2R,3R,6R)-3-benzyloxy-1-(methoxycarbonyl)-2-(methoxymethoxy)methyl-6-(trityloxy)-methylpiperidine

: 153198-46-0
(2S,3R,6R)-3-benzyloxy-1-(methoxycarbonyl)-2-(methoxymethoxy)methyl-6-(trityloxy)-methylpiperidine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 16h; Ambient temperature;
DOI:10.1016/S0040-4020(01)85638-6

Reference yield:

: (3R,6R)-3-benzyloxy-1-(methoxycarbonyl)-6-(trityloxy)-methyl-2-vinylpiperidine

: 153198-46-0
(2S,3R,6R)-3-benzyloxy-1-(methoxycarbonyl)-2-(methoxymethoxy)methyl-6-(trityloxy)-methylpiperidine

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) ozone, triphenylphosphine; 2.) NaBH₄ / CH₂Cl₂; methanol / 1.) -78 deg C, 45 min; 2.) 0 deg C, 2 h

2: 76 percent / i-Pr₂NEt / CH₂Cl₂ / 16 h / Ambient temperature

With sodium tetrahydroborate; ozone; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In methanol; dichloromethane;
DOI:10.1016/S0040-4020(01)85638-6