benzyl 4-(3-((1-(quinolin-2-yl)azetidin-3-yl)oxy)quinoxalin-2-yl)piperidine-1-carboxylate

Base Information

Chemical Name:benzyl 4-(3-((1-(quinolin-2-yl)azetidin-3-yl)oxy)quinoxalin-2-yl)piperidine-1-carboxylate
CAS No.:1350606-93-7
Molecular Formula:C₃₃H₃₁N₅O₃
Molecular Weight:545.641
Hs Code.:

Synonyms:benzyl 4-(3-((1-(quinolin-2-yl)azetidin-3-yl)oxy)quinoxalin-2-yl)piperidine-1-carboxylate

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Chemical Property of benzyl 4-(3-((1-(quinolin-2-yl)azetidin-3-yl)oxy)quinoxalin-2-yl)piperidine-1-carboxylate

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Technology Process of benzyl 4-(3-((1-(quinolin-2-yl)azetidin-3-yl)oxy)quinoxalin-2-yl)piperidine-1-carboxylate

There total 4 articles about benzyl 4-(3-((1-(quinolin-2-yl)azetidin-3-yl)oxy)quinoxalin-2-yl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 858670-79-8
(1-((benzyloxy)carbonyl)piperidin-4-yl)zinc(II) iodide

: 1350607-49-6
2-chloro-3-((1-(quinolin-2-yl)azetidin-3-yl)oxy)quinoxaline

: 1350606-93-7
benzyl 4-(3-((1-(quinolin-2-yl)azetidin-3-yl)oxy)quinoxalin-2-yl)piperidine-1-carboxylate

Guidance literature:: With copper(l) iodide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In N,N-dimethyl acetamide; at 80 ℃; for 2h; Inert atmosphere;
DOI:10.1016/j.bmc.2014.10.013

Reference yield:

: 885275-00-3
4-iodo-piperidine-1-carboxylic acid benzyl ester

: 1350606-93-7
benzyl 4-(3-((1-(quinolin-2-yl)azetidin-3-yl)oxy)quinoxalin-2-yl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: chloro-trimethyl-silane; zinc / ethylene dibromide; N,N-dimethyl acetamide / 0.5 h / Inert atmosphere

2: copper(l) iodide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl acetamide / 2 h / 80 °C / Inert atmosphere

With copper(l) iodide; chloro-trimethyl-silane; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; zinc; In N,N-dimethyl acetamide; ethylene dibromide;
DOI:10.1016/j.bmc.2014.10.013

Reference yield:

: 1340423-65-5
1-quinolin-2-yl-azetidin-3-ol

: 1350606-93-7
benzyl 4-(3-((1-(quinolin-2-yl)azetidin-3-yl)oxy)quinoxalin-2-yl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 - 20 °C

1.2: 90 °C

2.1: copper(l) iodide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl acetamide / 2 h / 80 °C / Inert atmosphere

With copper(l) iodide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium hydride; In N,N-dimethyl acetamide; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.bmc.2014.10.013