1-(tert-Butoxycarbonyl)-6-methoxyindole

Base Information

• Chemical Name: 1-(tert-Butoxycarbonyl)-6-methoxyindole
• CAS No.: 138344-18-0
• Molecular Formula: C14H17NO3
• Molecular Weight: 247.294
• Hs Code.: 2933990090
• Mol file: 138344-18-0.mol

Synonyms:tert-Butyl 6-methoxy-1H-indole-1-carboxylate;

Chemical Property of 1-(tert-Butoxycarbonyl)-6-methoxyindole

Chemical Property:

• Vapor Pressure: 2.75E-05mmHg at 25°C
• Refractive Index: 1.531
• Boiling Point: 357.3 °C at 760 mmHg
• Flash Point: 169.9 °C
• PSA: 40.46000
• Density: 1.1 g/cm³
• LogP: 3.43310
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

tert-butyl6-methoxy-1H-indole-1-carboxylate 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-Boc-6-methoxyindole is used as a reactant in the preparation of substituted indoles for treating hepatitis C.

Technology Process of 1-(tert-Butoxycarbonyl)-6-methoxyindole

There total 5 articles about 1-(tert-Butoxycarbonyl)-6-methoxyindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

6-methoxylindole (3189-13-7) + di-tert-butyl dicarbonate (24424-99-5) → tert-butyl 6-methoxy-1H-indole-1-carboxylate (138344-18-0)

Guidance literature:

With dmap; In dichloromethane; at 20 ℃; for 8h; Inert atmosphere;

DOI:10.1016/j.tet.2009.06.071

Reference yield:

2-Hydroxy-6-methoxy-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester (138344-17-9) → tert-butyl 6-methoxy-1H-indole-1-carboxylate (138344-18-0)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; for 0.0833333h; Yield given; Ambient temperature;

DOI:10.1055/s-1991-26597

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → tert-butyl 6-methoxy-1H-indole-1-carboxylate (138344-18-0)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrahydrofuran / Heating

2: 1a) s-BuLi, 2) DMF / 1a) THF, cyclohexane, -45 to -55 deg C, 30 min, 1b) -> -15 deg C, 60 min, 2) -45 deg C, 5 min

3: 12N HCl / tetrahydrofuran / 0.08 h / Ambient temperature

With hydrogenchloride; sec.-butyllithium; N,N-dimethyl-formamide; In tetrahydrofuran;

DOI:10.1055/s-1991-26597

upstream raw materials:

2-Hydroxy-6-methoxy-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester

di-tert-butyl dicarbonate

(5-methoxy-2-methyl-phenyl)-carbamic acid t-butyl ester

5-methoxy-o-toluidine

Downstream raw materials:

6-methoxylindole

tert-butyl 6-methoxyindoline-1-carboxylate

[1-(tert-butoxycarbonyl)-6-methoxy-1H-indol-2-yl]boronic acid

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 138344-18-0 1-(tert-Butoxycarbonyl)-6-methoxyindole

Send

Send

Metric Ton KG G Pound L ML

Send

Send