2-AMINO-5-METHYLTHIAZOLE

Base Information

• Chemical Name: 2-AMINO-5-METHYLTHIAZOLE
• CAS No.: 55502-89-1
• Molecular Formula: C5H7 N S
• Molecular Weight: 113.183
• Hs Code.: 2934999090
• Mol file: 55502-89-1.mol

Synonyms:2-Amino-5-methylthiophene;5-Methyl-2-thiophenamine

Chemical Property of 2-AMINO-5-METHYLTHIAZOLE

Chemical Property:

• Melting Point: 93-98 °C(lit.)
• Boiling Point: 206.2±20.0 °C(Predicted)
• PKA: 2.94±0.10(Predicted)
• PSA: 67.15000
• Density: 1.161±0.06 g/cm3(Predicted)
• LogP: 1.61490
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

5-Methylthiophen-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn,N
• Hazard Codes: Xn,N
• Statements: 22-48/22-50/53
• Safety Statements: 60-61

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-AMINO-5-METHYLTHIAZOLE

There total 2 articles about 2-AMINO-5-METHYLTHIAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

2-lithio-5-methylthiophene (63762-42-5) → 5-amino-2-methylthiophene (55502-89-1)

Guidance literature:

With 1-azidostyrene; In tetrahydrofuran; for 2h; from -78 deg.C to room temp.;

DOI:10.1016/S0040-4039(00)86925-7

Reference yield:

→ 5-amino-2-methylthiophene (55502-89-1)

Guidance literature:

Reference yield: 84.0%

5-amino-2-methylthiophene (55502-89-1) + 3-methyl-4-phenoxyaniline (191284-80-7) + bis(trichloromethyl) carbonate (32315-10-9) → 1-(3-methyl-4-phenoxyphenyl)-3-(5-methylthiophen-2-yl)urea

Guidance literature:

5-amino-2-methylthiophene; bis(trichloromethyl) carbonate; With sodium hydrogencarbonate; In dichloromethane; at 0 ℃; for 4h;

3-methyl-4-phenoxyaniline; With sodium hydrogencarbonate; In dichloromethane; at 0 - 25 ℃; for 16h;

upstream raw materials:

2-lithio-5-methylthiophene

Downstream raw materials:

(5-Methyl-thiophen-2-yl)-[1-(3-nitro-phenyl)-meth-(E)-ylidene]-amine

2,6-Dimethyl-4-(3-nitro-phenyl)-4,7-dihydro-thieno[2,3-b]pyridine-5-carboxylic acid methyl ester

Refernces