ethyl 5-(4-{4-[1-(2-chlorophenyl)ethoxycarbonylamino]-3-isoxazolyl}phenyl)-4-pentanoate

Base Information

Chemical Name:ethyl 5-(4-{4-[1-(2-chlorophenyl)ethoxycarbonylamino]-3-isoxazolyl}phenyl)-4-pentanoate
CAS No.:946149-68-4
Molecular Formula:C₂₅H₂₇ClN₂O₅
Molecular Weight:470.953
Hs Code.:

Synonyms:ethyl 5-(4-{4-[1-(2-chlorophenyl)ethoxycarbonylamino]-3-isoxazolyl}phenyl)-4-pentanoate

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Chemical Property of ethyl 5-(4-{4-[1-(2-chlorophenyl)ethoxycarbonylamino]-3-isoxazolyl}phenyl)-4-pentanoate

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Technology Process of ethyl 5-(4-{4-[1-(2-chlorophenyl)ethoxycarbonylamino]-3-isoxazolyl}phenyl)-4-pentanoate

There total 5 articles about ethyl 5-(4-{4-[1-(2-chlorophenyl)ethoxycarbonylamino]-3-isoxazolyl}phenyl)-4-pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.2%

: 946149-67-3
ethyl 5-(4-{4-[1-(2-chlorophenyl)ethoxycarbonylamino]-3-isoxazolyl}phenyl)-4-pentenoate

: 946149-68-4
ethyl 5-(4-{4-[1-(2-chlorophenyl)ethoxycarbonylamino]-3-isoxazolyl}phenyl)-4-pentanoate

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; for 1h;
DOI:10.1016/j.bmcl.2007.04.024

Reference yield:

: 839718-33-1
methyl 3-(4-iodophenyl)isoxazole-4-carboxylate

: 946149-68-4
ethyl 5-(4-{4-[1-(2-chlorophenyl)ethoxycarbonylamino]-3-isoxazolyl}phenyl)-4-pentanoate

Guidance literature:: Multi-step reaction with 4 steps

1: aq. LiOH / tetrahydrofuran / 1 h / 20 °C

2: DPPA; NEt₃ / toluene / 2 h / 90 °C

3: 64 percent / o-tol3P; DIEA / Pd(OAc)2 / dioxane / 4 h / Heating

4: 92 percent / H₂ / Pd/C / ethyl acetate / 1 h

With lithium hydroxide; diphenyl-phosphinic acid; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; tris-(o-tolyl)phosphine; palladium diacetate; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; ethyl acetate; toluene; 3: Heck reaction;
DOI:10.1016/j.bmcl.2007.04.024

Reference yield:

: 839718-34-2
3-(4-iodophenyl)isoxazole-4-carboxylic acid

: 946149-68-4
ethyl 5-(4-{4-[1-(2-chlorophenyl)ethoxycarbonylamino]-3-isoxazolyl}phenyl)-4-pentanoate

Guidance literature:: Multi-step reaction with 3 steps

1: DPPA; NEt₃ / toluene / 2 h / 90 °C

2: 64 percent / o-tol3P; DIEA / Pd(OAc)2 / dioxane / 4 h / Heating

3: 92 percent / H₂ / Pd/C / ethyl acetate / 1 h

With diphenyl-phosphinic acid; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; tris-(o-tolyl)phosphine; palladium diacetate; palladium on activated charcoal; In 1,4-dioxane; ethyl acetate; toluene; 2: Heck reaction;
DOI:10.1016/j.bmcl.2007.04.024