1-(2-chloro-5-(methylthio)phenyl)-3-(3-(difluoromethoxy)phenyl)guanidine

Base Information

Chemical Name:1-(2-chloro-5-(methylthio)phenyl)-3-(3-(difluoromethoxy)phenyl)guanidine
CAS No.:1415399-00-6
Molecular Formula:C₁₅H₁₄ClF₂N₃OS
Molecular Weight:357.811
Hs Code.:

Synonyms:1-(2-chloro-5-(methylthio)phenyl)-3-(3-(difluoromethoxy)phenyl)guanidine

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Chemical Property of 1-(2-chloro-5-(methylthio)phenyl)-3-(3-(difluoromethoxy)phenyl)guanidine

Chemical Property:

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Technology Process of 1-(2-chloro-5-(methylthio)phenyl)-3-(3-(difluoromethoxy)phenyl)guanidine

There total 4 articles about 1-(2-chloro-5-(methylthio)phenyl)-3-(3-(difluoromethoxy)phenyl)guanidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1415399-72-2
N-(3-(difluoromethoxy)phenyl)cyanamide

: 2-chloro-5-(methylthio)aniline hydrochloride

: 1415399-00-6
1-(2-chloro-5-(methylthio)phenyl)-3-(3-(difluoromethoxy)phenyl)guanidine

Guidance literature:: In chlorobenzene; Inert atmosphere; Heating;
DOI:10.1016/j.bmc.2014.12.029

Reference yield:

: t-butyl (2-chloro-5-(methylthio)phenyl)carbamate

: 1415399-00-6
1-(2-chloro-5-(methylthio)phenyl)-3-(3-(difluoromethoxy)phenyl)guanidine

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / tetrahydrofuran; water / 6 h / Reflux

2: chlorobenzene / Inert atmosphere; Heating

With hydrogenchloride; In tetrahydrofuran; water; chlorobenzene;
DOI:10.1016/j.bmc.2014.12.029

Reference yield:

: 51546-12-4
2-chloro-5-(methylthio)benzoic acid

: 1415399-00-6
1-(2-chloro-5-(methylthio)phenyl)-3-(3-(difluoromethoxy)phenyl)guanidine

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; diphenyl phosphoryl azide / 6 h / Reflux

2: hydrogenchloride / tetrahydrofuran; water / 6 h / Reflux

3: chlorobenzene / Inert atmosphere; Heating

With hydrogenchloride; diphenyl phosphoryl azide; triethylamine; In tetrahydrofuran; water; chlorobenzene;
DOI:10.1016/j.bmc.2014.12.029