tert-butyl (1-hydroxycyclohexyl)acetate

Base Information

• Chemical Name: tert-butyl (1-hydroxycyclohexyl)acetate
• CAS No.: 5292-13-7
• Molecular Formula: C12H22 O3
• Molecular Weight: 214.305
• Mol file: 5292-13-7.mol

Synonyms:Cyclohexaneaceticacid, 1-hydroxy-, tert-butyl ester (6CI,7CI,8CI); NSC 8348

Chemical Property of tert-butyl (1-hydroxycyclohexyl)acetate

Chemical Property:

• Vapor Pressure: 0.000301mmHg at 25°C
• Boiling Point: 286.3°Cat760mmHg
• Flash Point: 109.4°C
• Density: 1.025g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-butyl (1-hydroxycyclohexyl)acetate

There total 6 articles about tert-butyl (1-hydroxycyclohexyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

bromoacetic acid tert-butyl ester (5292-43-3) + cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → 1-(tert-Butoxy-2-oxoethyl)cyclohexanol (5292-13-7)

Guidance literature:

With tetrakis(trimethylphosphine)cobalt⁽⁰⁾; In tetrahydrofuran; for 0.25h; Ambient temperature;

DOI:10.1021/jo00080a001

Reference yield: 45.0%

3,3-dimethyl-1-(1-hydroxycyclohexyl)-2-butanone (59671-45-3) → 1-(tert-Butoxy-2-oxoethyl)cyclohexanol (5292-13-7)

Guidance literature:

With disodium hydrogenphosphate; trifluoroacetyl peroxide; In dichloromethane; for 1h; Heating;

DOI:10.1021/jo00193a008

Reference yield:

acetic acid tert-butyl ester (540-88-5) + cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → 1-(tert-Butoxy-2-oxoethyl)cyclohexanol (5292-13-7)

Guidance literature:

With lithium amide;

DOI:10.1021/ja01101a016

upstream raw materials:

acetic acid tert-butyl ester

cyclohexanone

bromoacetic acid tert-butyl ester

3,3-dimethyl-1-(1-hydroxycyclohexyl)-2-butanone

Downstream raw materials:

(1-Butyrylamino-cyclohexyl)-essigsaeure

(1-β-Naphthoylamino-cyclohexyl)-essigsaeure

(1-o-Toluoylamino-cyclohexyl)-essigsaeure

(1-Diphenylacetylamino-cyclohexyl)-essigsaeure

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