1-METHYL-1-PYRIDIN-3-YL-ETHYLAMINE

Base Information

• Chemical Name: 1-METHYL-1-PYRIDIN-3-YL-ETHYLAMINE
• CAS No.: 99980-40-2
• Molecular Formula: C₈H₁₂N₂
• Molecular Weight: 136.197
• Hs Code.: 2933399090
• Mol file: 99980-40-2.mol

Synonyms:Pyridine,3-(1-amino-1-methylethyl)- (6CI); [1-Methyl-1-(pyridin-3-yl)ethyl]amine

Chemical Property of 1-METHYL-1-PYRIDIN-3-YL-ETHYLAMINE

Chemical Property:

• Boiling Point: 110 °C(Press: 15 Torr)
• PKA: 8.81±0.25(Predicted)
• PSA: 38.91000
• Density: 0.997±0.06 g/cm3(Predicted)
• LogP: 1.97570
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98%Min ^*data from raw suppliers

1-Methyl-1-pyridin-3-yl-ethylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-METHYL-1-PYRIDIN-3-YL-ETHYLAMINE

There total 2 articles about 1-METHYL-1-PYRIDIN-3-YL-ETHYLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

pyridine-3-carbonitrile (100-54-9,121697-66-3,1232169-17-3,68271-95-4) + methyllithium (917-54-4) → 1-methyl-1-pyridin-3-ylethylamine (99980-40-2)

Guidance literature:

methyllithium; With cerium(III) chloride; In tetrahydrofuran; diethyl ether; at -78 ℃; for 0.5h; Inert atmosphere;

pyridine-3-carbonitrile; In tetrahydrofuran; diethyl ether; at -78 - 20 ℃; for 4h; Inert atmosphere;

DOI:10.1021/ml4004952

Reference yield:

→ 1-methyl-1-pyridin-3-ylethylamine (99980-40-2)

Guidance literature:

With trimethylsilylazide; boron trifluoride diethyl etherate; In toluene; at 20 ℃; for 0.25h;

With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield: 53.0%

1-methyl-1-pyridin-3-ylethylamine (99980-40-2) + (1-oxiranyl-2-phenylethyl)carbamic acid tert-butyl ester (98760-08-8,98818-34-9,98818-35-0,103127-56-6,98737-29-2) → [(1S,2R)-1-benzyl-2-hydroxy-3-(1-methyl-1-pyridin-3-ylethylamino)propyl]carbamic acid tert-butyl ester

Guidance literature:

In isopropyl alcohol; at 70 ℃; for 24h; Inert atmosphere;

DOI:10.1021/ml4004952

upstream raw materials:

pyridine-3-carbonitrile

methyllithium

Downstream raw materials:

N-[(1S,2R)-1-benzyl-2-hydroxy-3-(1-methyl-1-pyridin-3-ylethylamino)propyl]-5-piperidin-1-yl-N',N'-dipropylisophthalamide

Refernces

• 1、 -. "COMPOUNDS USEFUL AS CCR9 MODULATORS". Page/Page column 116. . Retrieved 2015/07/15.
• 2、 Watterson, Scott H.,Chen, Ping,Zhao, Yufen,Gu, Henry H.,Dhar, T. G. Murali,Xiao, Zili,Ballentine, Shelley K.,Shen, Zhongqi,Fleener, Catherine A.,Rouleau, Katherine A.,Obermeier, Mary,Yang, Zheng,McIntyre, Kim W.,Shuster, David J.,Witmer, Mark,Dambach, Donna,Chao, Sam,Mathur, Arvind,Chen, Bang-Chi,Barrish, Joel C.,Robl, Jeffrey A.,Townsend, Robert,Iwanowicz, Edwin J.. "Acridone-based inhibitors of inosine 5′-monophosphate dehydrogenase: Discovery and SAR leading to the identification of N-(2-(6-(4-ethylpiperazin-1- yl)pyridin-3-yl)propan-2-yl)-2-fluoro-9-oxo-9,10-dihydroacridine-3-carboxamide (BMS-566419)". . p. 3730 - 3742. Retrieved 2008/02/12.