(2S,4R)-4-((tert-butoxycarbonyl)amino)-2-methyl-5-phenylpentanoic acid

Base Information

• Chemical Name: (2S,4R)-4-((tert-butoxycarbonyl)amino)-2-methyl-5-phenylpentanoic acid
• CAS No.: 368870-65-9
• Molecular Formula: C₁₇H₂₅NO₄
• Molecular Weight: 307.39
• Mol file: 368870-65-9.mol

Synonyms:(2S,4R)-4-((tert-butoxycarbonyl)amino)-2-methyl-5-phenylpentanoic acid

Chemical Property of (2S,4R)-4-((tert-butoxycarbonyl)amino)-2-methyl-5-phenylpentanoic acid

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,4R)-4-((tert-butoxycarbonyl)amino)-2-methyl-5-phenylpentanoic acid

There total 28 articles about (2S,4R)-4-((tert-butoxycarbonyl)amino)-2-methyl-5-phenylpentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

(2S,4R)-4-amino-2-methyl-5-phenylpentanoic acid + di-tert-butyl dicarbonate (24424-99-5) → (2S,4R)-4-((tert-butoxycarbonyl)amino)-2-methyl-5-phenylpentanoic acid (368870-65-9)

Guidance literature:

With sodium hydroxide; In acetonitrile; at 20 ℃;

Reference yield: 77.0%

C23H34N2O5 (1173283-52-7) → (2S,4R)-4-((tert-butoxycarbonyl)amino)-2-methyl-5-phenylpentanoic acid (368870-65-9)

Guidance literature:

With lithium hydroxide; dihydrogen peroxide; In tetrahydrofuran; water; Inert atmosphere;

DOI:10.1016/j.tetlet.2009.04.046

Reference yield: 75.0%

tert-butyl (5R)-5-benzyl-3-methyl-2-oxopyrrolidine-1-carboxylate → (2S,4R)-4-((tert-butoxycarbonyl)amino)-2-methyl-5-phenylpentanoic acid (368870-65-9)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; at 23 ℃; for 3h;

DOI:10.1021/jm701321p

upstream raw materials:

C₂₃H₃₄N₂O₅

di-tert-butyl dicarbonate

(3R,5R)-tert-butyl 5-benzyl-3-methyl-2-oxopyrrolidine-1-carboxylate

(3S)-4-<(tert-butyldimethylsilyl)oxy>-3-methylbutanol

Downstream raw materials:

(R)-4-tert-butoxycarbonylamino-3-methyl-5-phenylpentanoic acid benzyl ester

methyl (2S,4R)-4-{[(2-{(1R,3R)-3-[(tert-butoxycarbonyl)amino]-1-hydroxy-4-methylpentyl}-1,3-thiazol-4-yl)carbonyl]amino}-2-methyl-5-phenylpentanoate

methyl (2S,4R)-4-{[(2-{(1R,3R)-1-acetoxy-3-[(tert-butoxycarbonyl)amino]-4-methylpentyl}-1,3-thiazol-4-yl)carbonyl]amino}-2-methyl-5-phenylpentanoate

methyl (2S,4R)-4-{[(2-{(6S,9R,11R)-6-[(2S)-butan-2-yl]-9-isopropyl-2,2-dimethyl-4,7,13-trioxo-3,12-dioxa-5,8-diazatetradecan-11-yl}-1,3-thiazol-4-yl)carbonyl]amino}-2-methyl-5-phenylpentanoate