cyclohexyl-(3,3-dimethylcyclopropen-1-yl)-methanol

Base Information

• Chemical Name: cyclohexyl-(3,3-dimethylcyclopropen-1-yl)-methanol
• CAS No.: 669073-14-7
• Molecular Formula: C₁₂H₂₀O
• Molecular Weight: 180.29
• Mol file: 669073-14-7.mol

Synonyms:cyclohexyl-(3,3-dimethylcyclopropen-1-yl)-methanol

Chemical Property of cyclohexyl-(3,3-dimethylcyclopropen-1-yl)-methanol

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of cyclohexyl-(3,3-dimethylcyclopropen-1-yl)-methanol

There total 1 articles about cyclohexyl-(3,3-dimethylcyclopropen-1-yl)-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

1,1,3‐tribromo‐2,2‐dimethylcyclopropane (23534-97-6) + cyclohexanecarbaldehyde (2043-61-0) → cyclohexyl-(3,3-dimethylcyclopropen-1-yl)-methanol (669073-14-7)

Guidance literature:

1,1,3‐tribromo‐2,2‐dimethylcyclopropane; With n-butyllithium; In diethyl ether; hexane; at -80 - -10 ℃;

cyclohexanecarbaldehyde; In diethyl ether; hexane; at -50 - 25 ℃;

DOI:10.1021/ol036143i

Reference yield: 75.0%

cyclohexyl-(3,3-dimethylcyclopropen-1-yl)-methanol (669073-14-7) → (1RS)-[(1RS)-3,3-dimethylcyclopropyl]-cyclohexyl methanol

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; at 0 - 40 ℃; for 19h;

DOI:10.1021/ol036143i

Reference yield: 65.0%

cyclohexyl-(3,3-dimethylcyclopropen-1-yl)-methanol (669073-14-7) → ((E)-4-Methyl-penta-1,3-dienyl)-cyclohexane (88001-21-2)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; benzene; at 80 ℃;

DOI:10.1055/s-2004-822918

upstream raw materials:

1,1,3‐tribromo‐2,2‐dimethylcyclopropane

cyclohexanecarbaldehyde

Downstream raw materials:

((E)-4-Methyl-penta-1,3-dienyl)-cyclohexane

Refernces

• 1、 Simaan, Samah,Masarwa, Ahmad,Zohar, Elinor,Stanger, Amnon,Bertus, Philippe,Marek, Ilan. "Cyclopropenylcarbinol derivatives as new versatile intermediates in organic synthesis: Application to the formation of enantiomerically pure alkylidenecyclopropane derivatives". supporting information; experimental part. p. 8449 - 8464. Retrieved 2010/06/15.