2-(1-allyl-1H-1,2,3-triazol-4-yl)-4-n-propylphenyl acetate

Base Information

Chemical Name:2-(1-allyl-1H-1,2,3-triazol-4-yl)-4-n-propylphenyl acetate
CAS No.:1375103-03-9
Molecular Formula:C₁₆H₁₉N₃O₂
Molecular Weight:285.346
Hs Code.:

Synonyms:2-(1-allyl-1H-1,2,3-triazol-4-yl)-4-n-propylphenyl acetate

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Chemical Property of 2-(1-allyl-1H-1,2,3-triazol-4-yl)-4-n-propylphenyl acetate

Chemical Property:

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Technology Process of 2-(1-allyl-1H-1,2,3-triazol-4-yl)-4-n-propylphenyl acetate

There total 4 articles about 2-(1-allyl-1H-1,2,3-triazol-4-yl)-4-n-propylphenyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 821-13-6
3-azido-propene

: 1375102-97-8
2-ethynyl-4-n-propylphenyl acetate

: 1375103-03-9
2-(1-allyl-1H-1,2,3-triazol-4-yl)-4-n-propylphenyl acetate

Guidance literature:: With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In water; dimethyl sulfoxide; at 20 - 70 ℃; for 13h;
DOI:10.1016/j.bmc.2012.03.028

Reference yield:

: 64080-16-6
2-bromo-4-propylphenol

: 1375103-03-9
2-(1-allyl-1H-1,2,3-triazol-4-yl)-4-n-propylphenyl acetate

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

2: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / 5 h / 80 °C / Inert atmosphere

3: water; caesium carbonate / acetonitrile / 2 h / 20 °C

4: copper(ll) sulfate pentahydrate; sodium L-ascorbate / water; dimethyl sulfoxide / 13 h / 20 - 70 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; copper(ll) sulfate pentahydrate; water; caesium carbonate; sodium L-ascorbate; triethylamine; In dichloromethane; water; dimethyl sulfoxide; acetonitrile; 2: Sonogashira coupling;
DOI:10.1016/j.bmc.2012.03.028

Reference yield:

: 645-56-7
4-n-Propylphenol

: 1375103-03-9
2-(1-allyl-1H-1,2,3-triazol-4-yl)-4-n-propylphenyl acetate

Guidance literature:: Multi-step reaction with 5 steps

1: bromine / chloroform / 12 h / 20 °C / Inert atmosphere

2: triethylamine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

3: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / 5 h / 80 °C / Inert atmosphere

4: water; caesium carbonate / acetonitrile / 2 h / 20 °C

5: copper(ll) sulfate pentahydrate; sodium L-ascorbate / water; dimethyl sulfoxide / 13 h / 20 - 70 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; copper(ll) sulfate pentahydrate; water; bromine; caesium carbonate; sodium L-ascorbate; triethylamine; In dichloromethane; chloroform; water; dimethyl sulfoxide; acetonitrile; 3: Sonogashira coupling;
DOI:10.1016/j.bmc.2012.03.028