N-((N-(arginyl-arginyl-prolyl-tyrosyl-isoleucyl-leucine)aminocarbonyl)ethyl)-N',N'',N'''-tris(2-(carboxy)ethyl)-1,4,8,11-tetraazacyclotetradecane

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Chemical Name:N-((N-(arginyl-arginyl-prolyl-tyrosyl-isoleucyl-leucine)aminocarbonyl)ethyl)-N',N'',N'''-tris(2-(carboxy)ethyl)-1,4,8,11-tetraazacyclotetradecane
CAS No.:1333054-56-0
Molecular Formula:C₆₀H₁₀₂N₁₆O₁₅
Molecular Weight:1287.57
Hs Code.:

Synonyms:N-((N-(arginyl-arginyl-prolyl-tyrosyl-isoleucyl-leucine)aminocarbonyl)ethyl)-N',N'',N'''-tris(2-(carboxy)ethyl)-1,4,8,11-tetraazacyclotetradecane

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Chemical Property of N-((N-(arginyl-arginyl-prolyl-tyrosyl-isoleucyl-leucine)aminocarbonyl)ethyl)-N',N'',N'''-tris(2-(carboxy)ethyl)-1,4,8,11-tetraazacyclotetradecane

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Technology Process of N-((N-(arginyl-arginyl-prolyl-tyrosyl-isoleucyl-leucine)aminocarbonyl)ethyl)-N',N'',N'''-tris(2-(carboxy)ethyl)-1,4,8,11-tetraazacyclotetradecane

There total 3 articles about N-((N-(arginyl-arginyl-prolyl-tyrosyl-isoleucyl-leucine)aminocarbonyl)ethyl)-N',N'',N'''-tris(2-(carboxy)ethyl)-1,4,8,11-tetraazacyclotetradecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: NT(8-13)

: 174025-02-6
1,4,8,11-tetrakis(2-carboxyethyl)-1,4,8,11-tetraazacyclotetradecane

: 1333054-56-0
N-((N-(arginyl-arginyl-prolyl-tyrosyl-isoleucyl-leucine)aminocarbonyl)ethyl)-N',N'',N'''-tris(2-(carboxy)ethyl)-1,4,8,11-tetraazacyclotetradecane

: 1333054-57-1
N,N'-bis((N-(arginyl-arginyl-prolyl-tyrosyl-isoleucyl-leucine)aminocarbonyl)ethyl)-N',N'',N'''-tris(2-(carboxy)ethyl)-1,4,8,11-tetraazacyclotetradecane

Guidance literature:: 1,4,8,11-tetrakis(2-carboxyethyl)-1,4,8,11-tetraazacyclotetradecane; With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-hydroxy-2,5-dioxopyrrolidine-3-sulfonic acid; In water; at 20 ℃; for 0.583333h;

NT(8-13); With disodium hydrogenphosphate; In water; for 24h; pH=8.5;
DOI:10.1016/j.jinorgbio.2011.02.011

Reference yield:

: 152588-96-0
N,N,N,N-tetrakis[2-(methoxycarbonyl)eth-1-yl]-1,4,8,11-tetraazacyclotetradecane

: 1333054-56-0
N-((N-(arginyl-arginyl-prolyl-tyrosyl-isoleucyl-leucine)aminocarbonyl)ethyl)-N',N'',N'''-tris(2-(carboxy)ethyl)-1,4,8,11-tetraazacyclotetradecane

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / water / 0.75 h / 20 °C

1.2: Dowex₅₀WX₈

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-hydroxy-2,5-dioxopyrrolidine-3-sulfonic acid / water / 0.58 h / 20 °C

2.2: 24 h / pH 8.5

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-hydroxy-2,5-dioxopyrrolidine-3-sulfonic acid; sodium hydroxide; In water;
DOI:10.1016/j.jinorgbio.2011.02.011

Reference yield:

: 295-37-4
1,4,8,11-Tetraazacyclotetradecane

: 1333054-56-0
N-((N-(arginyl-arginyl-prolyl-tyrosyl-isoleucyl-leucine)aminocarbonyl)ethyl)-N',N'',N'''-tris(2-(carboxy)ethyl)-1,4,8,11-tetraazacyclotetradecane

Guidance literature:: Multi-step reaction with 3 steps

1.1: methanol / 144 h / 20 °C

2.1: sodium hydroxide / water / 0.75 h / 20 °C

2.2: Dowex₅₀WX₈

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-hydroxy-2,5-dioxopyrrolidine-3-sulfonic acid / water / 0.58 h / 20 °C

3.2: 24 h / pH 8.5

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-hydroxy-2,5-dioxopyrrolidine-3-sulfonic acid; sodium hydroxide; In methanol; water; 1.1: Michael addition;
DOI:10.1016/j.jinorgbio.2011.02.011