2-(2-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-2H-1,2,3,4-tetrazol-5-yl)acetic acid

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Chemical Name:2-(2-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-2H-1,2,3,4-tetrazol-5-yl)acetic acid
CAS No.:937055-67-9
Molecular Formula:C₂₅H₂₄ClN₅O₅
Molecular Weight:509.949
Hs Code.:

Synonyms:2-(2-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-2H-1,2,3,4-tetrazol-5-yl)acetic acid

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Chemical Property of 2-(2-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-2H-1,2,3,4-tetrazol-5-yl)acetic acid

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Technology Process of 2-(2-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-2H-1,2,3,4-tetrazol-5-yl)acetic acid

There total 10 articles about 2-(2-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-2H-1,2,3,4-tetrazol-5-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 937055-55-5
ethyl 2-(2-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-2H-1,2,3,4-tetrazol-5-yl)acetate

: 937055-67-9
2-(2-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-2H-1,2,3,4-tetrazol-5-yl)acetic acid

Guidance literature:: ethyl 2-(2-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-2H-1,2,3,4-tetrazol-5-yl)acetate; With potassium carbonate; In tetrahydrofuran; methanol; water; at 20 ℃; Heating;

With acetic acid; In tetrahydrofuran; methanol; water;
DOI:10.1016/j.bmc.2012.02.054

Reference yield:

: 2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl methanesulfonate

: 937055-67-9
2-(2-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-2H-1,2,3,4-tetrazol-5-yl)acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: tetra-(n-butyl)ammonium iodide; potassium carbonate

2: potassium carbonate / tetrahydrofuran; methanol; water / 20 °C / Heating

With tetra-(n-butyl)ammonium iodide; potassium carbonate; In tetrahydrofuran; methanol; water;
DOI:10.1016/j.bmc.2012.02.054

Reference yield:

: 937057-51-7
methyl (E)-3-{1-[4-chloro-2-(2,3-dimethoxybenzoyl)phenyl]-1H-pyrrol-2-yl}-2-propenoate

: 937055-67-9
2-(2-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-2H-1,2,3,4-tetrazol-5-yl)acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1: sodium tetrahydroborate / methanol / 1 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 8 h / 20 °C

3: CHIRALCEL OD column / hexane; isopropyl alcohol / Resolution of racemate

4: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 °C

5: triethylamine / dichloromethane / 3 h / 0 °C

6: tetra-(n-butyl)ammonium iodide; potassium carbonate

7: potassium carbonate / tetrahydrofuran; methanol; water / 20 °C / Heating

With sodium tetrahydroborate; lithium aluminium tetrahydride; tetra-(n-butyl)ammonium iodide; potassium carbonate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; hexane; dichloromethane; water; isopropyl alcohol; 2: Michael reaction;
DOI:10.1016/j.bmc.2012.02.054