Technology Process of 3α-(2-Hydroxyphenyl)-5α-cholestan-2α-ol
There total 8 articles about 3α-(2-Hydroxyphenyl)-5α-cholestan-2α-ol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogen;
10percent Pd/C;
In
tetrahydrofuran;
at 20 ℃;
for 24h;
DOI:10.1039/a905697a
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: Mg; 1,2-dibromoethane / tetrahydrofuran / 0.5 h
1.2: 30 percent / tetrahydrofuran / 1 h
2.1: 48 percent / PTSA*H20 / toluene / 24 h / 20 °C
3.1: 48 percent / m-CPBA / CH2Cl2 / 2 h / 20 °C
4.1: 86 percent / BF3*OEt2 / CH2Cl2 / 0.83 h / 0 °C
5.1: 73 percent / NaOMe / methanol; CH2Cl2 / 8 h / pH 9 - 10 / Heating
6.1: 5 percent / LAH / tetrahydrofuran / 1.5 h
7.1: 97 percent / H2 / 10percent Pd/C / tetrahydrofuran / 24 h / 20 °C
With
lithium aluminium tetrahydride; hydrogen; sodium methylate; toluene-4-sulfonic acid; magnesium; ethylene dibromide; 3-chloro-benzenecarboperoxoic acid;
boron trifluoride diethyl etherate;
In
tetrahydrofuran; methanol; dichloromethane; toluene;
1.1: Grignard reaction / 1.2: Addition / 2.1: Dehydration / 3.1: Epoxidation / 4.1: Rearrangement / 5.1: Epimerization / 6.1: Reduction / 7.1: Hydrogenolysis;
DOI:10.1039/a905697a
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: Mg; 1,2-dibromoethane / tetrahydrofuran / 0.5 h
1.2: 30 percent / tetrahydrofuran / 1 h
2.1: 48 percent / PTSA*H20 / toluene / 24 h / 20 °C
3.1: 48 percent / m-CPBA / CH2Cl2 / 2 h / 20 °C
4.1: 86 percent / BF3*OEt2 / CH2Cl2 / 0.83 h / 0 °C
5.1: 73 percent / NaOMe / methanol; CH2Cl2 / 8 h / pH 9 - 10 / Heating
6.1: 5 percent / LAH / tetrahydrofuran / 1.5 h
7.1: 97 percent / H2 / 10percent Pd/C / tetrahydrofuran / 24 h / 20 °C
With
lithium aluminium tetrahydride; hydrogen; sodium methylate; toluene-4-sulfonic acid; magnesium; ethylene dibromide; 3-chloro-benzenecarboperoxoic acid;
boron trifluoride diethyl etherate;
In
tetrahydrofuran; methanol; dichloromethane; toluene;
1.1: Grignard reaction / 1.2: Addition / 2.1: Dehydration / 3.1: Epoxidation / 4.1: Rearrangement / 5.1: Epimerization / 6.1: Reduction / 7.1: Hydrogenolysis;
DOI:10.1039/a905697a
