2-(4-((1R,2R)-2-(((3,5-difluoro-4-(methylsulfonyl)benzyl)oxy)methyl)cyclopropyl)piperidin-1-yl)-5-(methoxymethyl)pyrimidine

Base Information

Chemical Name:2-(4-((1R,2R)-2-(((3,5-difluoro-4-(methylsulfonyl)benzyl)oxy)methyl)cyclopropyl)piperidin-1-yl)-5-(methoxymethyl)pyrimidine
CAS No.:1416365-78-0
Molecular Formula:C₂₃H₂₉F₂N₃O₄S
Molecular Weight:481.564
Hs Code.:

Synonyms:2-(4-((1R,2R)-2-(((3,5-difluoro-4-(methylsulfonyl)benzyl)oxy)methyl)cyclopropyl)piperidin-1-yl)-5-(methoxymethyl)pyrimidine

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Chemical Property of 2-(4-((1R,2R)-2-(((3,5-difluoro-4-(methylsulfonyl)benzyl)oxy)methyl)cyclopropyl)piperidin-1-yl)-5-(methoxymethyl)pyrimidine

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Technology Process of 2-(4-((1R,2R)-2-(((3,5-difluoro-4-(methylsulfonyl)benzyl)oxy)methyl)cyclopropyl)piperidin-1-yl)-5-(methoxymethyl)pyrimidine

There total 11 articles about 2-(4-((1R,2R)-2-(((3,5-difluoro-4-(methylsulfonyl)benzyl)oxy)methyl)cyclopropyl)piperidin-1-yl)-5-(methoxymethyl)pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.5%

: 1416366-34-1
2-chloro-5-(methoxymethyl)pyrimidine

: 1416366-78-3
4-((1R,2R)-2-(((3,5-difluoro-4-(methylsulfonyl)benzyl)oxy)methyl)cyclopropyl)piperidine hydrochloride

: 1416365-78-0
2-(4-((1R,2R)-2-(((3,5-difluoro-4-(methylsulfonyl)benzyl)oxy)methyl)cyclopropyl)piperidin-1-yl)-5-(methoxymethyl)pyrimidine

Guidance literature:: With caesium carbonate; In dimethyl sulfoxide; at 20 - 60 ℃; Inert atmosphere;

Reference yield:

: 473299-49-9
3,5-difluoro-4-(methylthio)benzaldehyde

: 1416365-78-0
2-(4-((1R,2R)-2-(((3,5-difluoro-4-(methylsulfonyl)benzyl)oxy)methyl)cyclopropyl)piperidin-1-yl)-5-(methoxymethyl)pyrimidine

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium tetrahydroborate / methanol / 1.5 h / 0 - 20 °C

2.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 48 h / 0 °C

3.1: sodium hydride / dichloromethane; mineral oil / 0.08 h / 0 °C

3.2: 0 - 20 °C

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C

5.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 1 h / 20 °C

6.1: caesium carbonate / dimethyl sulfoxide / 0.08 h / 20 °C / Inert atmosphere

With hydrogenchloride; sodium tetrahydroborate; carbon tetrabromide; sodium hydride; caesium carbonate; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; In 1,4-dioxane; methanol; dichloromethane; dimethyl sulfoxide; mineral oil;
DOI:10.1021/acsmedchemlett.5b00207

Reference yield:

: 132123-54-7
3,4,5-trifluorobenzaldehyde

: 1416365-78-0
2-(4-((1R,2R)-2-(((3,5-difluoro-4-(methylsulfonyl)benzyl)oxy)methyl)cyclopropyl)piperidin-1-yl)-5-(methoxymethyl)pyrimidine

Guidance literature:: Multi-step reaction with 7 steps

1.1: dimethyl sulfoxide / 0.28 h / 125 °C / Microwave irradiation

2.1: sodium tetrahydroborate / methanol / 1.5 h / 0 - 20 °C

3.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 48 h / 0 °C

4.1: sodium hydride / dichloromethane; mineral oil / 0.08 h / 0 °C

4.2: 0 - 20 °C

5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C

6.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 1 h / 20 °C

7.1: caesium carbonate / dimethyl sulfoxide / 0.08 h / 20 °C / Inert atmosphere

With hydrogenchloride; sodium tetrahydroborate; carbon tetrabromide; sodium hydride; caesium carbonate; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; In 1,4-dioxane; methanol; dichloromethane; dimethyl sulfoxide; mineral oil;
DOI:10.1021/acsmedchemlett.5b00207