2,4(1H,3H)-Pyrimidinedione, 1-[2-deoxy-2-fluoro-5-O-[(4-methoxyphenyl)diphenylmethyl]-β-D-arabinofuranosyl]-5-methyl-

Base Information

Chemical Name:2,4(1H,3H)-Pyrimidinedione, 1-[2-deoxy-2-fluoro-5-O-[(4-methoxyphenyl)diphenylmethyl]-β-D-arabinofuranosyl]-5-methyl-
CAS No.:121353-88-6
Molecular Formula:C30H29 F N2 O6
Molecular Weight:532.568
Hs Code.:

Synonyms:2,4(1H,3H)-Pyrimidinedione, 1-[2-deoxy-2-fluoro-5-O-[(4-methoxyphenyl)diphenylmethyl]-β-D-arabinofuranosyl]-5-methyl-

Suppliers and Price of 2,4(1H,3H)-Pyrimidinedione, 1-[2-deoxy-2-fluoro-5-O-[(4-methoxyphenyl)diphenylmethyl]-β-D-arabinofuranosyl]-5-methyl-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 3 raw suppliers

Chemical Property of 2,4(1H,3H)-Pyrimidinedione, 1-[2-deoxy-2-fluoro-5-O-[(4-methoxyphenyl)diphenylmethyl]-β-D-arabinofuranosyl]-5-methyl-

Chemical Property:

PSA：102.78000
LogP:3.45870

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2,4(1H,3H)-Pyrimidinedione, 1-[2-deoxy-2-fluoro-5-O-[(4-methoxyphenyl)diphenylmethyl]-β-D-arabinofuranosyl]-5-methyl-

There total 3 articles about 2,4(1H,3H)-Pyrimidinedione, 1-[2-deoxy-2-fluoro-5-O-[(4-methoxyphenyl)diphenylmethyl]-β-D-arabinofuranosyl]-5-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 69256-17-3,163252-36-6,2923-73-1
1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)thymine

: 14470-28-1
mono-4-methoxytrityl chloride

: 121353-88-6
1-<5-O-(monomethoxytrityl)-2-fluoro-2-deoxy-β-D-arabinofuransosyl>thymine

Guidance literature:: With pyridine;
DOI:10.1081/NCN-120022961

Reference yield:

: 22224-41-5
1,3,5-tri-O-benzoyl-α-D-ribofuranoside

: 121353-88-6
1-<5-O-(monomethoxytrityl)-2-fluoro-2-deoxy-β-D-arabinofuransosyl>thymine

Guidance literature:: Multi-step reaction with 4 steps

1.1: 83 percent / [bis(2-methoxyethyl)amino]sulfur trifluoride / CH₂Cl₂ / 50 °C

2.1: 90 percent / HBr / CH₂Cl₂ / 24 h / 20 °C

3.1: CCl₄ / 72 h / 77 °C

3.2: NH₄OH / methanol / 24 h / 20 °C

4.1: 87 percent / pyridine

With pyridine; hydrogen bromide; (bis-(2-methoxyethyl)amino)sulfur trufluoride; In tetrachloromethane; dichloromethane;
DOI:10.1081/NCN-120022961

Reference yield:

: 97614-43-2
1,3,5-tri-O-benzoyl-2-deoxy-2-fluoro-α-D-arabinofuranose

: 121353-88-6
1-<5-O-(monomethoxytrityl)-2-fluoro-2-deoxy-β-D-arabinofuransosyl>thymine

Guidance literature:: Multi-step reaction with 3 steps

1.1: 90 percent / HBr / CH₂Cl₂ / 24 h / 20 °C

2.1: CCl₄ / 72 h / 77 °C

2.2: NH₄OH / methanol / 24 h / 20 °C

3.1: 87 percent / pyridine

With pyridine; hydrogen bromide; In tetrachloromethane; dichloromethane;
DOI:10.1081/NCN-120022961